Drug Discovery News - "Mount Sinai Lab Uncovers Epigenetic Activity in Depression"

 – February 26, 2013  –– 

A team of researchers from the Icahn School of Medicine at Mount Sinai have identified the epigenetic regulation of a protein called Rac1, which induces synaptic remodeling in stress disorders and depression.  "We started probing the known regulators of synaptic structure, things that might have driven our earlier findings in 2011," says Dr. Scott Russo, assistant professor of neuroscience at the Graduate School of Biomedical Sciences at Mount Sinai. "We think our data makes a good argument for the epigenetic cause of depression, an experiential cause. Epigenetics is the study of things that control your genome that are above the genome, not in the genetic sequence itself. We found in mouse models that there are individual differences in how the epigenome expresses itself in response to stress." Learn more