Resilient Together for Dementia
The proposed study will establish the feasibility, acceptability and credibility of a novel
live video dyadic resiliency intervention, Resilient Together for Dementia (RT-D), aimed at
preventing chronic emotional distress and preserving quality of life among dyads a...
Age: 65 years - 66+
Gender: All
Alzheimer's Plasma Extension
The APEX study is a multicenter, observational study designed to capture longitudinal
follow-up of plasma biomarkers and cognitive and functional assessments on individuals who
screen failed in the AHEAD study over approximately 4 years.
Approximately 1000 parti...
Age: 55 - 80 years
Gender: All
Assessment of Supportive Care and Educational Needs to Guide Quality Care Improvements for Patients With Locally Advanced and Metastatic Bladder Cancer
The overall goal of this study is to facilitate care improvements for bladder cancer patients with locally advanced or metastatic disease by designing and evaluating a patient need assessment screening tool to be used, in the future, as standard screening measure. Adult...
Age: 18 - 89 years
Gender: All
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
Study Design:
This is an international, multicenter, observational, non-interventional, prospective,
blinded, single-arm, two-period study, to collect patient utterances that will be
retrospectively analyzed to determine the sensitivity and UPNR of the HearO sys...
Age: 22 years - 66+
Gender: All
Frequency of Glucose Monitoring in Labor
The aim of this study is to assess rates of neonatal hypoglycemia with differing intrapartum
glucose protocols. Currently at this time there is no guidance from professional medical
organizations about when and how frequent to assess maternal glucose levels intrapar...
Age: 18 years - 66+
Gender: Female
Ritlecitinib in Patients With Keloids or Those Undergoing Keloidectomy
Keloids are common, benign cutaneous overgrowths that manifest clinically as raised, hypertrophic, often hyperpigmented lesions which are formed in response to dermal injury or idiopathic stimuli. Although keloids are a common disease, it's exact incidence and prevalenc...
Age: 18 years - 66+
Gender: All
Intratumoral and Systemic Hiltonol® (Poly-ICLC) in Prostate Cancer Patients on Active Surveillance
This is a partially blinded randomized controlled phase II pilot study comparing Poly-ICLC (Hiltonol®) treatment vs no treatment, for prostate cancer participants on active surveillance.
Age: 18 years - 66+
Gender: Male
Bimekizumab in Plaque Psoriasis
The purpose of this research study is to evaluate the effectiveness and safety of bimekizumab
in individuals with moderate-to-severe psoriasis who have failed similar therapies.
Bimekizumab improves psoriasis by suppressing a type of substance found in bodies called...
Age: 18 years - 66+
Gender: All
Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy
PlAcebo versus erector spINae pLane block for mEdical ThoracoScopy Study (PAINLESS). This is
a prospective triple-blind, randomized controlled trial that evaluates the efficacy of
erector spinae plane block (ESPB) with Bupivacaine in reducing pain after medical
th...
Age: 18 years - 66+
Gender: All
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing
cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease
or are at risk of a heart attack or stroke. The study drug will be administered
subcutaneo...
Age: 18 years - 66+
Gender: All
Behavioral and Cognitive Predictors of Persistent Pain and Opioid Misuse in Chronic Pain
Chronic lower back pain (CLBP) affects approximately 20% of the global population. The study objective is to determine if impulsivity, inhibitory control, drug choice, and/or cognitive distortions predict opioid misuse and disability in patients with chronic pain. This ...
Age: 18 years - 66+
Gender: All
Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
The purpose of this study is to assess the effectiveness, safety, and tolerability of
BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's
Disease.
Age: 50 - 80 years
Gender: All
Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease
Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel
disease (IBD), who often experience a relapsing disease course, is an essential component of
care. Improving IBD disease control is linked to increased health-related quality of l...
Age: 18 years - 66+
Gender: All
A Central Preservation and Assessment Service to Optimize Donor Kidney Allocation
This is a study to collect information to assess if transporting hard-to-place (HTP) donor
kidneys to a central preservation and assessment facility with dedicated organ assessment
capabilities increases allocation success to transplant hospitals.
Age: 16 - 75 years
Gender: All
Different Medications to Induce Labor
This is a randomized controlled trial examining whether the use of misoprostol or pitocin, in
combination with a foley catheter, is more effective at inducing labor in patients with a
gravid BMI that is considered obese.
Age: 18 years - 66+
Gender: Female
Transcutaneous Electrical Nerve Stimulation (TENS) for IUD Insertion Pain
This study is a double-blind, randomized, placebo-controlled trial to evaluate the use of high frequency TENS for pain control during IUD insertion. Transcutaneous electrical nerve stimulation (TENS) is a relatively low-cost, low-risk, non-pharmacologic intervention for...
Age: 18 years - 66+
Gender: All
Impact of Intraoperative Cell Salvage
Patients presenting for elective cesarean section will be screened for pre-procedural anemia. If the potential subject meets the selection criteria they will be presented with the option of participating in the study. Once consented the participant is randomized by enve...
Age: 18 years - 66+
Gender: Female
Tier - Palliative Care For Patients With Advanced Heart Failure or Cancer
TIER-PC is an adaptive model of delivering palliative care that provides the right level of
care to the right patients at the right time. It represents an adaption of the Mount Sinai
PALLIATIVE CARE AT HOME (PC@H) program, which delivers home-based palliative care. ...
Age: 18 years - 66+
Gender: All
VOLT-AF IDE Clinical Study
This clinical investigation is intended to demonstrate safety and effectiveness of the Volt™ Pulsed Field Ablation (PFA) Catheter Sensor Enabled™, the Volt™ PFA Generator, Agilis™ NxT Steerable Introducer Dual-Reach™, and EnSite™ X EP...
Age: 18 years - 66+
Gender: All
Neural Circuit Effects of Ketamine in Depression
This project is designed to examine the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in humans with depression, as well as the acute and sustained effects of ketamine on agACC activation and depression symptoms.
Age: 18 - 65 years
Gender: All