Syed A Morshed, PhD Email Syed Morshed
- INSTRUCTOR | Medicine, Endocrinology, Diabetes and Bone Disease
Syed A Morshed, PhD, is an Instructor of Medicine, Division of Endocrinology, Diabetes and Bone Disease. Dr. Morshed is a dedicated and experienced scientist with an MBBS and a PhD and a proven track record of understanding disease mechanisms and molecular actions of drugs and monoclonal antibodies. Strong expertise in immunooncology, lymphocytes, cell biology, signal transduction, immunology, inflammation, antibodies, autoimmunity, cancer, diagnostic biomarkers, drug discovery, and high-throughput assay development. Ability to develop drugs that target receptors, ligands, organs and tissues as selective therapies. Served as an IACUC review committee. Editing profound number of papers in peer-reviewed journals. Experienced with process enhancements, continuous improvement procedures, quality assurance, and ongoing program evaluation to support organizational goals.
Antibiotic Resistance, Antibody Development, Autoimmunity, Cytokines, Hepatitis C Virus, Liver, Lymphocytes, T Cells, Thyroid
MBBS, Dhaka University
PhD, Kagawa Medical University
Monbusho Scholarship for PhD
Large DNA Molecule Cloning
Cold Spring Harbor, NY
Young Clinician Award
American Gastroenterology Association, LA
European Society for Autoimmune Disease
Institute Pasteur, Paris
Society for Mucosal Immunology
Japanese Society of Gastroenterology
Monbusho Scholarship for Research
Neuroimmunology & Endocrinology
Animal models, perfusion, neuronal cell culture, immunohistochemistry (frozen sections, fixed tissue section, free floating, antigen retrieval), Immunofluorescent, protein purification from brain, cell--‐based assay, staining of astrocyte, microglia, oligodendrocytes and neurons, thyroid cell signaling, animal models of thyroid autoimmunity. TSH receptor antibody‐induced Signal transduction with kinase assays, proteomics by antibody array, and System Biology.
TSHR‐agonist & antagonist, high-throughput screening.
Protein chemistry): Centrifugations, affinity purification, gel purification, 1-D, 2‐D gel‐electrophoresis, Western blot, EMSA, FPLC, HPLC, digestion, microsequencing, mass spectrometry, etc.
(a) Antibody Research: Preparation of polyclonal and Monoclonal antibodies, purification and detection by immunofluorescence, immunodiffusion, radioimmunoassay, ELISA, Luminex, immunoblots, immunoprecipitation, and FACS. Lymphocyte characterization: Isolation, culture, co--‐culture, cloning, proliferation and cytotoxicity assays, ELISPOT, apoptosis, phenotype analyses by FACS and adoptive transfer experiments. (b) Animal models: Autoimmune, graft vs. host disease, transplantation, and antibody--‐mediated neurological disease in SCID, nude mice and rat models. (c) Signal transduction: Lymphocyte & Epithelial cells – GPCR, BCR and ROS. Ras/cRaf/B--‐Raf/MAPK NFkB, NFAT, Caspase/FAS, Bcl--‐2, Bcl--‐xL, Bcl--‐6, CD40/CD40L, TLR, etc. (d) Mitochondria, endoplasmic reticulum, golgi, and vesicular trafficking (endosome--‐lysosome) and sorting.
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Dr.Morshed did not report having any of the following types of financial relationships with industry during 2020 and/or 2021: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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