Susan K Fried, PhD Email Susan Fried
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- Position
- PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
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- Language
- English
Research Topics
Adipose, Biochemistry, Extracellular Matrix, Gene Expressions, Growth Factors and Receptors, Inflammation, Obesity, Receptors, Stem Cells, Translation, Translational Research, cAMP
Education
AB, Barnard College
MS, Columbia Univ. Institute of Human Nutrition
PhD, Columbia University
, Emory University
, Medical College of Pennsylvania
Language
English
2005
Obesity Research Editor’s Choice Reviewer Award
1994
NJ Agricultural Experiment Station Research Award
Cardiovascular, Cell Biology, Cellular Differentiation, Diabetes, Extracellular Matrix, Fibrosis, Gene Expressions, Genomics, Growth, Hormones, Insulin, Lipid Signaling, Microarray, Obesity, Oxidative Phosphorylation, Oxidative Stress, Protein Transl
Central obesity, especially visceral obesity, is associated with higher risk for metabolic disease such as Type 2 diabetes. On the other hand, peripheral obesity, i.e. ‘pear-shaped’ with more storage around hips and thighs decreases risk of metabolic disease, independent of total body fat. The goal of my lab’s research is to understand the physiological, cellular and molecular mechanisms that regulate adipose tissue distribution and its relationship to metabolic health. We use in vivo and in vitro approaches to understand the differential sensitivity of visceral and subcutaneous adipose tissues to the lipogenic and anti-inflammatory effects of glucocorticoids. We are also building on our early studies of metabolic differences among fat depots in men and women with analyses of genes and secreted proteins that are expressed in a sex- and depot-dependent manner. Using primary cell culture and organ culture, our basic research focuses on translationally important questions in adipose tissue biology: 1) how the adipocyte functions as an endocrine cell that can detect the level of body fat and response to the metabolic needs of the organism, and 2) mechanisms that control human adipose tissue remodeling and growth, 3) mechanisms regulating lipid droplet biology and fat oxidation in human adipocytes. A long-term goal is to develop novel therapies for obesity and related diseases by understanding the interaction of genetic and nutritional influences on susceptibility to obesity and metabolic disease, and sex- and racial differences in these relationships.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr.Fried did not report having any of the following types of financial relationships with industry during 2020 and/or 2021: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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