
Scott L Friedman, MD Email Scott Friedman

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- Positions
- DEAN FOR THERAPEUTIC DISCOVERY
- PROFESSOR | Medicine, Liver Diseases
- PROFESSOR | Pharmacological Sciences
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- Specialties
- Liver Medicine
- Gastroenterology
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- Language
- English
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- Hospital Affiliations
- The Mount Sinai Hospital
- Mount Sinai Morningside and Mount Sinai West
Research Topics
Aerodigestive Tract, Anti-Tumor Therapy, Apoptosis/Cell Death, Autophagy, Biomedical Sciences, Cancer Genetics, Cell Biology, Cell Transformation, Developmental Biology, Drug Resistance, Endothelial Cells, Epithelial Cells, Extracellular Matrix, Fibrosis, Gene Regulation, Growth Factors and Receptors, Hepatitis C Virus, Integrins, Knockout Mice, Liver, Macrophage, Metastasis, Molecular Biology, Organogenesis, Oxidative Stress, Phosphorylation, Proteases, Receptors, Signal Transduction, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice, Tumor Suppressor Genes, Tumorigenesis, Vascular Development, Wound Healing
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Pharmacology and Therapeutics Discovery [PTD]
Education
BS, Rensselaer Polytechnic Institute
MD, Mount Sinai School of Medicine
Residency, Internal Medicine
Beth Israel Hospital
Residency, Internal Medicine
Beth Israel Hospital
Fellowship, Gastroenterology
University of California Hospitals
Language
English
2016
Am Assn for the Study of Liver Diseases Distinguished Achievement Award
AASLD
Recognizes an outstanding body fo work contributing to the advancement of hepatology science
2016
American Liver Foundation Distinguished Achievement Award
American Liver Foundation
Recognizes an outstanding body fo work contributing to the advancement of hepatology science
2015
Maud Menten Honorary Lecture
U. Pittsburgh
Lecture honoring the founding Chair of Pathology
2015
Burton Combes Memorial Lecture
UT Southwestern GI Division
Lecture honoring the memory of the former Chief of GI
2015
Charles Lieber Memorial Lecture
American Gastroenterological Assn
Lecture honoring the contributions of Charles Lieber MD, to gastroenterology and hepatology
2015
Emmet B Keeffe Mentoring Award
Recognizes outstanding mentorship in the field of hepatology
2015
Fellow, American Assn for the Advancement fo Science
AAAS
Recognizes outstanding leadership in American science
2014
The Jacobi Medallion
The Icahn School of Medicine at Mount Sinai
The highest honor bestowed by the school for contributions to its mission
2014
Salute to Excellence Award
American Liver Foundation, San Francisco Chapter
Recognizing outstanding contributions to liver research and clinical care
2014
Fellow
Am Assn for the Study of Liver Diseases
2014
President
American Assn for the Study of Liver Diseases
2014
Rao Honorary Lecture
Feinberg School of Medicine, Northwestern U.
2014
China Friendship Award
Chinese Government, presented by the Premier of China
Recognizes outstanding contributions to advances benefiting the people of China
2013
Shanghai Magnolia Gold Award
City of Shanghai
Recognizing outstanding contributions to the City of Shanghai
2013
International Recognition Award
European Assn for the Study of LIver
Recognizes an international leader in the science of liver diseases
2012
Master Educator Recognition
Mount Sinai Institute for Medical Education
2010
Englert Lecture
University of Utah Dept of Medicine
2009
Rafael Research Alumni Visiting Scientist
Rambam Hospital, Haifa, Israel
2009
Sheila Sherlock Lecture
British Assn for Gastroenterology, Liverpool, UK
2008
Sackler Distinguished Lectureship
Tel Aviv University, Israel
2008
Fellow of the American Gastroenterological Assn
2008
Ken & Louise Goldberg Visiting Professor
Brigham and Women's Hospital, Boston MA
2006
Solomon Berson Dept of Medicine Housestaff Teaching Award
2004
International Hans Popper Research Prize
Falk foundation
Recognizes the most outstanidng liver scientist in the world under the age of 50 years old
2003
International Hans Popper Award to Outstanding Researcher in Hepatology
1995
Fulbright Senior Scholar Award
1979
Arthur H. Aufses Sr., Prize in Surgery
Mount Sinai School of Medicine
Mechanisms of Hepatic Fibrosis and Cancer
Dr. Friedman is the Director of both the Division of Liver Diseaases and the Fibrosis Research Center, and is co-Director of the Tisch Cancer Institute Liver Cancer Program
Specific Clinical/Research Interest:
- Cellular and molecular mechanisms of hepatic fibrosis and cancer
- Diagnosis and development of anti-fibrotic therapies for patients with chronic liver disease
- Clinical trials of antifibrotic therapies in patients with chronic liver disease
Current Students: Billie Bian PhD Student, Fatemah Parvin-Nejad, MD Student; Benjamin Wooden, MD Student
Current Postdoctoral Fellows: Youngjoon Yoon, MD; Takuma Tsuchida PhD;
Research Personnel: Hsin Chou, M.S. (Lab Manager); Dipankar Bhattacharya, M.S.
Summary of Research Studies:
Our work explores the molecular mechanisms of wound healing and fibrosis in liver and how they contribute to liver cancer. We use a variety of animal and cell culture models to identify key inflammatory mediatiors and signaling molecules regulating the activation of hepatic stellate cells, the principle fibrogenic cells in liver. Additionally, we test candidate antifibrotic lead compounds to develop potential new therapies for patients with chronic fibrosing liver diseases. Specific projects include:
- Molecular mechanisms of hepatic stellate cell activation and the cell's role iin hepatic regeneration, immunity and repair
-Testing of antifibrotic lead compounds in animal models
-Clinical trials of antifibrotic therapies in patients with chronic liver disease
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Friedman during 2020 and/or 2021. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting:
- 89Bio
- Amgen Inc.
- Axcella health
- Blade Therapeutics
- Bristol-Myers Squibb
- CanFite BioPharma Ltd.
- Chemomab
- Coherus
- Escient Pharmaceuticals
- Forbion Capiltal Partners
- Genevant
- Genfit Pharmaceuticals
- Glycotest
- Gordian Biotechnology
- Indalo Therapeutics
- Metacrine
- Northsea Therapeutics
- Novartis
- ONO PHARMACEUTICAL CO., LTD.
- Pfizer Inc.
- Surrozen
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Blade Therapeutics
- CanFite BioPharma Ltd.
- Glympse Bio Inc
- Gordian Biotechnology
- Group K Diagnostics
- Indalo Therapeutics
- Lifemax
- Metacrine
- Nimbus Discovery LLC
- North Sea Therapeutics
- Surrozen
Royalty Payments:
- Chugai Pharmaceutical Co., Ltd.
- F. Hoffman-La Roche Ltd.
- Life Technologies Corporation
- Mitsubishi Tanabe Pharma Corporation
- Nitto Denko Corporation
- Novartis
Scientific Advisory Board:
- Glympse Bio
- Morphic Therapeutics
- Scholar Rock, Cambridge MA
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.