- DEAN FOR TRANSLATIONAL BIOMEDICAL RESEARCH
- PROFESSOR | Pediatrics, Pulmonary and Critical Care
- PROFESSOR | Environmental Medicine & Public Health
- PROFESSOR | Medicine, Pulmonary, Critical Care and Sleep Medicine
During medical school, she was selected to spend a year as a Howard Hughes Research Scholar at the National Institutes of Health in Bethesda, Maryland further pursuing research in molecular biology. Following medical school, Dr. Wright completed an internship in Internal Medicine at the Beth Israel Hospital, Harvard Medical School. She then moved to Chicago, Illinois to complete her residency in Internal Medicine at Northwestern University where she also served as Chief Medical Resident. She then returned to Boston to complete fellowship training in Pulmonary and Critical Care Medicine at Harvard Medical School. As part of this training she obtained a Masters in Public Health degree from the Harvard School of Public Health. In 1997, she joined the clinical faculty at the Beth Israel Deaconess Medical Center and the research faculty at the Channing Laboratory, Brigham & Women’s Hospital, Harvard Medical School and the Harvard School of Public Health where she remained on the faculty until she was recruited to Mount Sinai as Vice Chair of Clinical & Translational Research in the Department of Pediatrics in August 2012.
Dr. Wright is a developmental epidemiologist with transdisciplinary training in environmental health and stress mechanisms. She has a primary interest in early life (prenatal and early childhood) predictors of developmental diseases including asthma, obesity, neurobehavioral development, and lung growth and development. A particular focus is on the implementation of studies considering the role of both social (e.g., psychosocial stress, other socioeconomic risk factors) and physical (e.g., air pollution, chemicals, dietary factors, allergens) environmental factors in explaining health disparities among lower-SES urban populations. Dr. Wright is the PI and Director of the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project as well as the Programming of Intergenerational Stress Mechanisms (PRISM) study funded by the National Heart, Lung & Blood Institute (NHLBI). This research program explores underlying mechanisms by incorporating biomarkers of physiological pathways through which psychological stress as well as chemical stressors may influence health (e.g., altered hypothalamic-pituitary-adrenal axis functioning, altered maturation of the immune system, disruption of the autonomic nervous system, and epigenetics).
Wright R, Visness C, Calatroni A, Grayson M, Gold D, Sandel M, Lee-Paritz A, Wood R, Kattan M, Bloomberg G, Burger M, Togias A, Witter F, Sperling R, Sadovsky Y, Gern J. Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city population. . Am J Resp Crit Care Med 2010; 182: 25-33.
Sternthal M, Jun H, Earls F, Wright R. Community violence and urban childhood asthma: A multilevel study.. Eur Resp J 2010; 36: 1400-9.
Sternthal M, Coull B, Chiu Y, Cohen S, Wright R. Associations among maternal childhood socioeconomic status, cord immunoglobulin E, and repeated wheeze in urban children. . J Allergy Clin Immunol 2011; 128: 337-45.
Nguyen K, Subramanian S, Sorensen G, Tsang K, Wright R. Influence of experiences of racial discrimination and ethnic identity on prenatal smoking among urban black and Hispanic women. . J Epidemiol Community Health 2012; 66: 315-21.
Enlow M, Egeland B, Blood E, Wright R, Wright R. Interpersonal trauma exposure and cognitive development in children to age 8 years: a longitudinal study. . J Epidemiol Community Health 2012; 66: 1005-10.
Chiu Y, Coull B, Cohen S, Wooley A, Wright R. Pre- and postnatal maternal stress and wheeze in urban children: effect of maternal sensitization. . Am J Respir & Crit Care Med 2012; 186: 147-54.
Chiu Y, Bellinger D, Coull B, Anderson S, Barber R, Wright R, Wright R. Associations between traffic-related black carbon exposure and attention in a prospective birth cohort of urban children.. Environ Health Perspect 2013;: [Epub ahead of print].
Wright R, Fisher K, Chiu Y, Wright R, Fein R, Cohen S, Coull B. Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze: Insights into prenatal programming.. Am J Respir Crit Care Med 2013; 187: 1186-93.
Lakshmanan A, Chiu YH, Coull BA, Just AC, Maxwell SL, Schwartz J, Gryparis A, Kloog I, Wright RJ, Wright RO. Associations between prenatal traffic-related air pollution exposure and birth weight: Modification by sex and maternal pre-pregnancy body mass index. Environmental research 2015 Jan; 137C.
Schreier HM, Hsu HH, Amarasiriwardena C, Coull BA, Schnaas L, Téllez-Rojo MM, Tamayo Y Ortiz M, Wright RJ, Wright RO. Mercury and psychosocial stress exposure interact to predict maternal diurnal cortisol during pregnancy. Environmental health : a global access science source 2015 Mar; 14(1).
Hsu HL, Chiu YM, Coull BA, Kloog I, Schwartz J, Lee A, Wright RO, Wright RJ. Prenatal Particulate Air Pollution and Asthma Onset in Urban Children: Identifying Sensitive Windows and Sex Differences. American journal of respiratory and critical care medicine 2015 Jul;.
Schreier HM, Enlow MB, Ritz T, Gennings C, Wright RJ. Childhood abuse is associated with increased hair cortisol levels among urban pregnant women. Journal of epidemiology and community health 2015 Jul;.
Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future Research Directions in Asthma: An NHLBI Working Group Report. American journal of respiratory and critical care medicine 2015 Aug;.
Gruenberg DA, Wright RJ, Visness CM, Jaffee KF, Bloomberg GR, Cruikshank WW, Kattan M, Sandel MT, Wood RA, Gern JE. Relation between stress and cytokine responses in inner-city mothers. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2015 Sep;.
Burris HH, Baccarelli AA, Wright RO, Wright RJ. Epigenetics, linking social and environmental exposures to preterm birth. Pediatric research 2015 Oct;.
Brunst KJ, Kannan S, Ni YM, Gennings C, Ganguri HB, Wright RJ. Validation of a Food Frequency Questionnaire for Estimating Micronutrient Intakes in an Urban US Sample of Multi-Ethnic Pregnant Women. Maternal and child health journal 2015 Oct;.
Cowell WJ, Bellinger DC, Coull BA, Gennings C, Wright RO, Wright RJ. Associations between Prenatal Exposure to Black Carbon and Memory Domains in Urban Children: Modification by Sex and Prenatal Stress. PloS one 2015 Nov; 10(11).
Schreier HM, Bosquet Enlow M, Ritz T, Coull BA, Gennings C, Wright RO, Wright RJ. Lifetime Exposure to Traumatic and Other Stressful Life Events and Hair Cortisol in a Multi-Racial/Ethnic Sample of Pregnant Women. Stress (Amsterdam, Netherlands) 2015 Nov;.
Chiu YM, Hsu HL, Coull BA, Bellinger DC, Kloog I, Schwartz J, Wright RO, Wright RJ. Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations. Environment international 2015 Nov; 87.
Austin C, Smith TM, Farahani RM, Hinde K, Carter EA, Lee J, Lay PA, Kennedy BJ, Sarrafpour B, Wright RJ, Wright RO, Arora M. Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific reports 2016 Jan; 6.
Rosa MJ, Just AC, Tamayo Y Ortiz M, Schnaas L, Svensson K, Wright RO, Téllez Rojo MM, Wright RJ. Prenatal and postnatal stress and wheeze in Mexican children: Sex-specific differences. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2016 Jan;.
Lee A, Wright RJ. Prenatal stress and childhood asthma risk: taking a broader view. The European respiratory journal 2016 Feb; 47(2).
Tamayo Y Ortiz M, Téllez-Rojo MM, Wright RJ, Coull BA, Wright RO. Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12-24 month-old infants from Mexico City. Environmental health : a global access science source 2016 Feb; 15(1).
Lee A, Mathilda Chiu YH, Rosa MJ, Jara C, Wright RO, Coull BA, Wright RJ. Prenatal and postnatal stress and asthma in children: Temporal- and sex-specific associations. The Journal of allergy and clinical immunology 2016 Mar;.
Niedzwiecki MM, Austin C, Remark R, Merad M, Gnjatic S, Estrada-Gutierrez G, Espejel-Nuñez A, Borboa-Olivares H, Guzman-Huerta M, Wright RJ, Wright RO, Arora M. A multimodal imaging workflow to visualize metal mixtures in the human placenta and explore colocalization with biological response markers. Metallomics : integrated biometal science 2016 Mar;.
Bosquet Enlow M, White MT, Hails K, Cabrera I, Wright RJ. The Infant Behavior Questionnaire-Revised: Factor structure in a culturally and sociodemographically diverse sample in the United States. Infant behavior & development 2016 Apr; 43.
AlSeaidan M, Al Wotayan R, Christophi CA, Al-Makhseed M, Abu Awad Y, Nassan F, Ahmed A, Abraham S, Boley RB, James-Todd T, Wright RJ, Dockery DW, Behbehani K. Birth Outcomes in a Prospective Pregnancy-Birth Cohort Study of Environmental Risk Factors in Kuwait: The TRACER Study. Paediatric and perinatal epidemiology 2016 May;.
Stroustrup A, Hsu HH, Svensson K, Schnaas L, Cantoral A, Solano González M, Torres-Calapiz M, Amarasiriwardena C, Bellinger DC, Coull BA, Téllez-Rojo MM, Wright RO, Wright RJ. Toddler temperament and prenatal exposure to lead and maternal depression. Environmental health : a global access science source 2016 Jun; 15(1).
Trump S, Bieg M, Gu Z, Thürmann L, Bauer T, Bauer M, Ishaque N, Röder S, Gu L, Herberth G, Lawerenz C, Borte M, Schlesner M, Plass C, Diessl N, Eszlinger M, Mücke O, Elvers HD, Wissenbach DK, von Bergen M, Herrmann C, Weichenhan D, Wright RJ, Lehmann I, Eils R. Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation. Scientific reports 2016 Jun; 6.
Brunst KJ, Rosa MJ, Jara C, Lipton LR, Lee A, Coull BA, Wright RJ. Impact of Maternal Lifetime Interpersonal Trauma on Children's Asthma: Mediation Through Maternal Active Asthma During Pregnancy. Psychosomatic medicine 2016 Jun;.
Karlsson O, Rodosthenous RS, Jara C, Brennan KJ, Wright RO, Baccarelli AA, Wright RJ. Detection of long non-coding RNAs in human breastmilk extracellular vesicles: Implications for early child development. Epigenetics 2016 Aug;.
Ramratnam SK, Visness CM, Jaffee KF, Bloomberg GR, Kattan M, Sandel MT, Wood RA, Gern JE, Wright RJ. Relationships Among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low Income Urban Families. American journal of respiratory and critical care medicine 2016 Sep;.
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Dr. Wright has not yet completed reporting of Industry relationships.
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