Roman Osman | Mount Sinai

About Me

Language

English

Position

PROFESSOR | Pharmacological Sciences

Research Topics

Antigen Presentation, Apoptosis/Cell Death, Autoimmunity, Biophysics, Cancer, Computational Biology, Computer Simulation, DNA Repair, Diabetes, Drug Design and Discovery, Enzymology, Gene Regulation, Mathematical and Computational Biology, Membrane Proteins/Channels, Post-Transcriptional Processing, Proteases, Protein Complexes, Protein Folding, Protein Structure/Function, Receptors, Signal Transduction, Structural Biology, T Cells, Theoretical Biophysics, Thermodynamics, Thyroid

Multi-Disciplinary Training Areas

Artificial Intelligence and Emerging Technologies in Medicine [AIET], Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)

Education

BS, Hebrew University

MS, Graduate School of the Hebrew University

PhD, Graduate School of Tel-Aviv University

, Vanderbilt University

Research

In collaboration with Dr. Iban Ubarretxena we are investigating the origin of selectivity of membrane-bound proteases. The hypothesis is that the secondary structure and dynamics of the helical portion of the substrate is regulating catalysis. To investigate this process we have developed a capability of conducting MD simulations in bilayers as well as in micelles. Our results provide a molecular interpretation of the observed changes in the substrate of GlpG and MCMRJ1, both membrane-bound proteases.