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Robert M Samstein, MD, PhD Email Robert Samstein

Radiation Oncology
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    • Position
    • ASSISTANT PROFESSOR | Radiation Oncology
    • Specialty
    • Radiation Oncology
    • Language
    • English
    • Hospital Affiliations
    • Mount Sinai Brooklyn
    • Mount Sinai Queens
    • The Mount Sinai Hospital
    • New York Eye and Ear Infirmary of Mount Sinai
    • Mount Sinai Beth Israel
    • Mount Sinai Morningside and Mount Sinai West
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Robert (Robbie) Samstein, MD PhD is a radiation oncologist in the Department of Radiation Oncology at Mount Sinai and a physician scientist with a laboratory in the Precision Immunology Institute at Mount Sinai. He treats a wide variety of cancer, specializing in thoracic malignancies. He graduated summa cum laude from Yale University and completed his combined MD-PhD training in the Tri-Institutional Weill Cornell/ Memorial Sloan Kettering/ Rockefeller MD-PhD Program. He completed his graduate work with Alexander Rudensky studying the development and function of regulatory T cells. He completed his transitional year internship and residency in radiation oncology at Memorial Sloan Kettering Cancer Center in New York, NY.  During residency, he conducted laboratory research with Dr. Timothy Chan as part of the American Board of Radiology Holman Research pathway.

Dr. Samstein’s research interests are focused on understanding the interaction between the patient’s immune system and cancer cells in the tumor, elucidating the role of the DNA damage repair and response pathway in altering the tumor’s ability to be recognized and attacked by the immune system. His laboratory will work to identify new strategies to harness the immune anti-tumor response and expand the therapeutic window of traditional immunotherapies.



Radiation Oncology

Clinical Focus

Research Topics

Anti-Tumor Therapy, Autoimmunity, Biomedical Sciences, Breast Cancer, Cancer, Cancer Genetics, Cellular Immunity, Clinical Genomics, DNA Recombination, DNA Repair, Genetics, Genomics, Immunology, Mucosal Immunology, Oncogenes, Personalized Medicine, Pharmacogenomics, T Cells, Translational Research, Tumor Suppressor Genes, Tumorigenesis

Multi-Disciplinary Training Areas

Cancer Biology [CAB], Genetics and Genomic Sciences [GGS], Immunology [IMM]


MD, Weill Cornell Medical College

MD, Weill Cornell Medical College

PhD, Weill Cornell / Sloan Kettering / Rockefeller Tri-I MD-PhD Program

, Memorial Sloan Kettering Cancer Center

Internship, Transitional Program
Memorial Sloan Kettering Cancer Center

Residency, Radiation Oncology
Memorial Sloan Kettering Cancer Center