Dr. Goldstein is a Professor of Psychiatry with a secondary appointment in the Department of Neuroscience at the Icahn School of Medicine in NY. Dr. Goldstein is chief of the Brain Imaging Core (BIC) at ISMMS; she also directs the NARC (Neuropsychoimaging of Addiction and Related Conditions) research group that uses multimodality functional neuroimaging methods to explore the neurobiological basis of impaired cognitive and emotional functioning in human drug addiction and other disorders of self-control. An important application of this research is to facilitate the development of intervention modalities that would improve treatment outcome in drug addiction and other chronically relapsing disorders of self-regulation.
Nationally and internationally known for her neuroimaging and neuropsychological studies in drug addiction, Dr. Goldstein formulated a theoretical model known as Impaired Response Inhibition and Salience Attribution (iRISA). The model uses multiple neuroimaging modalities—including MRI, EEG/ERP, PET and neuropsychological tests—to explore the neurobiological underpinnings of iRISA in drug addiction and related conditions. Her work has contributed to the development of relevant machine-learning algorithms for innovative analyses applied to this multidimensional data set.
Dr. Goldstein’s interests also include pharmacological fMRI, including administering oral methylphenidate to cocaine addicted individuals to improve self-control, neurofeedback such as Brain Computer Interface, and brain stimulation with Transcranial Magnetic Stimulation. She has also been exploring the contribution of individual differences, including polymorphisms in monoaminergic genes, to addiction and aggression, with a focus on the neural mechanisms underlying reinforcement learning and extinction, choice and decision-making, and self-awareness and insight into severity of illness.
Dr. Goldstein received her B.A. degree (double major in Psychology and French), cum laude, from Tel Aviv University, Israel, in 1992. She received her Ph.D. degree in Health Clinical Psychology, with award of academic merit, from the University of Miami, FL, in 1999, after completing a yearlong internship in clinical neuropsychology at the Long Island Jewish Medical Center, NY. She then completed her post-doctorate training on a fellowship on Brain Imaging and Alcohol Abuse from the National Institutes of Health, under the mentorship of Nora D. Volkow (director of NIDA). Dr. Goldstein received her license in clinical psychology in 2002. Dr. Goldstein became Assistant Scientist at the medical research department at Brookhaven National Laboratory in 2002, advancing to the Associate position in 2004, and to a Scientist position in 2006; tenure was awarded in 2008. Dr. Goldstein moved to the Icahn School of Medicine in January 2013. Dr. Goldstein is also an affiliate in the departments of psychology and biomedical engineering at State University of New York at Stony Brook. She has authored or co-authored numerous well-cited peer-reviewed manuscripts and book chapters, focusing on the role of the prefrontal cortex in addiction. She became member of the American College of Neuropsychopharmacology (ACNP) in January 2010, receiving the prestigious Joel Elkes Research Award in 2012 and the Jacob P. Waletzky Award in 2013. Goldstein’s research has been independently funded by several federal and private agencies (including NIDA, NIMH, and National Alliance for Research on Schizophrenia and Depression).
BA, Tel Aviv University
Internship, Long Island Jewish Medical Center
PhD, University of Miami
Post-doc fellow, Brookhaven National Laboratory
Clinical Research Education Program [CLR], Neuroscience [NEU], Public Health [PH]
Jacob P. Waletzky Award
Outstanding Alumni Award
Department of Psychology, University of Miami, FL
Joel Elkes Research Award
American College of Neuropsychopharmacology (ACNP)
Nominated as Member
American College of Neuropsychopharmacology (ACNP)
Outstanding Mentor Award
Brookhaven National Laboratory
Woman of the Year in Science
Young Investigator Award
National Alliance for Research on Schizophrenia And Depression (NARSAD)
Comorbid depression in cocaine-dependent adults: neurocognitive predictors of relapse
Mentored Patient-Oriented Research Career Development Award
Behavioral correlates of fMRI response in cocaine users
Konova AB, Moeller SJ, Tomasi D, Volkow ND, Goldstein RZ. Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction. JAMA psychiatry (Chicago, Ill.) 2013 Aug; 70(8).
Moeller SJ, Parvaz MA, Shumay E, Beebe-Wang N, Konova AB, Alia-Klein N, Volkow ND, Goldstein RZ. Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jun; 33(24).
Goldstein RZ, Volkow ND. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nature reviews. Neuroscience 2011 Nov; 12(11).
Volkow ND, Tomasi D, Wang GJ, Fowler JS, Telang F, Goldstein RZ, Alia-Klein N, Woicik P, Wong C, Logan J, Millard J, Alexoff D. Positive emotionality is associated with baseline metabolism in orbitofrontal cortex and in regions of the default network. Molecular psychiatry 2011 Aug; 16(8).
Alia-Klein N, Parvaz MA, Woicik PA, Konova AB, Maloney T, Shumay E, Wang R, Telang F, Biegon A, Wang GJ, Fowler JS, Tomasi D, Volkow ND, Goldstein RZ. Gene x disease interaction on orbitofrontal gray matter in cocaine addiction. Archives of general psychiatry 2011 Mar; 68(3).
Volkow ND, Baler RD, Goldstein RZ. Addiction: pulling at the neural threads of social behaviors. Neuron 2011 Feb; 69(4).
Volkow ND, Wang GJ, Newcorn JH, Kollins SH, Wigal TL, Telang F, Fowler JS, Goldstein RZ, Klein N, Logan J, Wong C, Swanson JM. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular psychiatry 2011 Nov; 16(11).
Goldstein RZ, Woicik PA, Maloney T, Tomasi D, Alia-Klein N, Shan J, Honorio J, Samaras D, Wang R, Telang F, Wang GJ, Volkow ND. Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task. Proceedings of the National Academy of Sciences of the United States of America 2010 Sep; 107(38).
Goldstein RZ, Craig AD, Bechara A, Garavan H, Childress AR, Paulus MP, Volkow ND. The neurocircuitry of impaired insight in drug addiction. Trends in cognitive sciences 2009 Sep; 13(9).
Goldstein RZ, Alia-Klein N, Tomasi D, Carrillo JH, Maloney T, Woicik PA, Wang R, Telang F, Volkow ND. Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction. Proceedings of the National Academy of Sciences of the United States of America 2009 Jun; 106(23).
Goldstein RZ, Tomasi D, Alia-Klein N, Honorio Carrillo J, Maloney T, Woicik PA, Wang R, Telang F, Volkow ND. Dopaminergic response to drug words in cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 May; 29(18).
Alia-Klein N, Goldstein RZ, Kriplani A, Logan J, Tomasi D, Williams B, Telang F, Shumay E, Biegon A, Craig IW, Henn F, Wang GJ, Volkow ND, Fowler JS. Brain monoamine oxidase A activity predicts trait aggression. The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 May; 28(19).
Goldstein RZ, Alia-Klein N, Tomasi D, Zhang L, Cottone LA, Maloney T, Telang F, Caparelli EC, Chang L, Ernst T, Samaras D, Squires NK, Volkow ND. Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?. The American journal of psychiatry 2007 Jan; 164(1).
Goldstein RZ, Volkow ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. The American journal of psychiatry 2002 Oct; 159(10).
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Dr.Goldstein did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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