Rebecca LR Powell, PhD Email Rebecca LR Powell
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- Position
- ASSISTANT PROFESSOR | Medicine, Infectious Diseases
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- Language
- English
Dr. Powell received her Bachelor’s of Science degree at the University of Toronto and her Ph. D. in Microbiology at the Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine. Dr. Powell's doctoral research focused on the genomic analysis of HIV in the epicenter of the HIV pandemic, West-Central Africa. While testing for HIV and collecting blood samples from study participants in Cameroon, she developed a low-cost method to rapidly detect HIV superinfection. This assay enabled the discovery that among this normal-risk population, superinfection was as common as primary infection, facilitating virus recombination and strongly impacting the genetic diversity of HIV in this region. Her further study of the impact of HIV superinfection on the host immune response led to the finding that these infections tended to broaden the HIV-specific neutralizing antibody response, suggesting inclusion of various HIV subtypes in a vaccine may do the same. Dr. Powell’s early post-doctoral research was performed at the International AIDS Vaccine Initiative (IAVI) Design and Development Lab, where she was part of the Candidate Evaluation team. Her work at IAVI involved the design and testing of replicating viral vector vaccines displaying HIV Envelope. She developed various antibody-based assays that allowed detailed evaluation of candidate vaccines in small and large animal studies, identifying several Vesicular Stomatitis Virus candidate vaccines in particular as safe and highly immunogenic, which are currently in clinical trials.
The overarching goals of Dr. Powell's research program at the Icahn School of Medicine at Mount Sinai are to understand the human milk immune response to infection and vaccination, and ultimately, to design maternal vaccines aimed to enhance this response.
The R. Powell Lab at the Icahn School of Medicine at Mount Sinai currently has several active projects aimed to fill knowledge gaps about human milk immunology and the milk immune response to infectious disease and vaccination:
1) Fc-mediated antibody function against HIV by relevant primary cells, with particular focus on antibody-dependent cellular phagocytosis (ADCP) by human milk leukocytes and its role in minimizing mother-to-child transmission (MTCT) of HIV via breastfeeding
2) Collaborative work with the Microbiology department to analyze the human milk immune response to seasonal influenza vaccination
3) Comprehensive assessment of SARS-CoV-2-reactive antibodies in human milk to determine their potential as a COVID-19 therapeutic and as a means to prevent infection of breastfed babies
4) Verification and assessment of an entero-mammary immunological link in Rhesus Macaques in order to provide critical data for designing maternal vaccines to eliminate mother-to-child-transmission of HIV via breastfeeding
Dr. Powell is also a certified lactation counselor, and lives in Brooklyn with her partner and 3 children.
Research Topics
Coronavirus, HIV/AIDS, Immunology, Infectious Disease, Influenza Virus, Mucosal Immunology, Vaccine Development
Language
English
Understanding the human milk immune response to infection and vaccination, and ultimately, to design maternal vaccines aimed to enhance this response
We currently have several active projects aimed to fill knowledge gaps about human milk immunology and the milk immune response to infectious disease and vaccination:
1) Fc-mediated antibody function against HIV by relevant primary cells, with particular focus on antibody-dependent cellular phagocytosis (ADCP) by human milk leukocytes and its role in minimizing mother-to-child transmission (MTCT) of HIV via breastfeeding
2) Collaborative work with the Microbiology department to analyze the human milk immune response to seasonal influenza vaccination
3) Comprehensive assessment of SARS-CoV-2-reactive antibodies in human milk to determine their potential as a COVID-19 therapeutic and as a means to prevent infection of breastfed babies
4) Verification and assessment of an entero-mammary immunological link in Rhesus Macaques in order to provide critical data for designing maternal vaccines to eliminate mother-to-child-transmission of HIV via breastfeeding
All project descriptions can be read about on the R. Powell Lab webpage (https://labs.icahn.mssm.edu/rebecca-powell-lab/)
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Powell during 2020 and/or 2021. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose
- CIG Media Group, L.P.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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