Rauf Latif, PhD Email Rauf Latif
- ASSOCIATE PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
PhD, Institute of Basic Medical Sciences
, Indian Institute of Science
, Weizmann Institute of Science
The Endocrine Society
The American Thyroid Association
Five year Predoctoral Fellowship
University Grants Commission, India
The thyroid stimulating hormone receptor (TSHR) expressed on the surface of thyroid epithelial cells is central to the regulation of thyroid growth, development and function. This unique GPCR undergoes complex post-translational processing such as intramolecular cleavage and oligomerization in addition to being localized to lipid rafts. Gaining insight into the regulation and signaling of this thyroid autoantigen is important pathophysiologically because of its extended presence in other extra-thyroidal tissues. Thus TSHR is important in thyroid autoimmunity, thyroid development and other extra-thyroidal conditions
Focus of the laboratory has been on understanding the role of these receptors in post-translational modifications and signaling. The receptors has also been a therapeutic target for the development of novel small molecules.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Latif has not yet completed reporting of Industry relationships.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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