Randall Holcombe, MD
- ADJUNCT PROFESSOR | Medicine, Hematology and Medical Oncology
In the News
Dr. Holcombe discusses treatment of colon cancer in The Daily News feature The Daily Check Up.
- Anal Cancer
- Colon Cancer
- Esophageal Cancer
- Gastric (Stomach) Cancer
- Liver Cancer
- Pancreatic Cancer
- Rectal Cancer
Best Doctors in America: 2005-2010; 2011-2015
Dr Holcombe's Research Interests
1. Colon cancer prevention: Colon cancer is the third leading cause of cancer death for both men and women in the United States. Preventing this disease through the development of novel agents, many of them derived from naturally occurring compounds, is an area of specific interest. These compounds are undergoing testing both in the laboratory and in pilot clinical trials.
2. Wnt Signaling in Cancer: The Wnt signal transduction pathway is critical for the development and progression of many cancers but colon cancer in particular. Laboratory research is ongoing which will define the role of specific components of the Wnt signaling pathway in colon cancer and define mechanisms by which activation of this pathway contributes to a malignant phenotype. These studies are performed with an eye toward the development of new diagnostic tests, validation of new prognostic markers, and implementation and testing of novel targeted therapeutic interventions.
3. Clinical and Translational Research: Dr. Holcombe’s major focus has been on the development of hypothesis-driven, investigator-initiated trials in the area of gastrointestinal malignancies. Currently, Dr. Holcombe has several clinical trials in development for the treatment of patients with colon cancer and other gastrointestinal malignancies.
4. Health Services and Healthcare Quality: Transitioning oncology care to value-based paradigms is essential and an area of research focus over the past several years. Dr. Holcombe has published numerous manuscripts related to healthcare quality and novel models of care delivery.