Photo of Randall Holcombe

Randall Holcombe, MD

    • Position
    • ADJUNCT PROFESSOR | Medicine, Hematology and Medical Oncology
    • Language
    • English
Randall F. Holcombe, MD is Chief Medical Officer, Cancer, Mount Sinai Health System; Professor of Medicine, Division of Hematology and Medical Oncology and Director of Clinical Cancer Affairs for Mount Sinai Medical Center. He has extensive experience in the conduct of clinical trials and is involved directly in clinical care and research for patients with colorectal cancer and other GI malignancies. Dr. Holcombe also serves as Director of the Ruttenberg Treatment Center at Mt. Sinai Hospital, Director of GI Medical Oncology and Deputy Director for the Tisch Cancer Institute.

A leading authority in colon cancer, Dr. Holcombe has broad experience ranging from basic science and translational research to clinical trials and patient care. His research initially focused on levamisole, an adjuvant treatment for people with stage III colon cancer, which led to a national clinical trial. His focus since 1997 has been on the signaling of a protein called Wnt and its role in colon cancer development and progression. He has served as the principal investigator on 141 clinical trials, and led the team that was the first to describe the selective expression of the LEF1 gene in colon cancer. His laboratory has been examining the clinical effects of a naturally-derived compound called resveratrol on the prevention or treatment of colon cancer. He is deeply involved in the promotion and facilitation of translational and clinical research. More recently, Dr. Holcombe has been involved in health services and quality focused cancer research. His research has been funded by the NIH and multiple foundations and has resulted in more than 100 peer-reviewed manuscript publications and more than 170 published conference abstracts.

In the News
Dr. Holcombe discusses treatment of colon cancer in The Daily News feature The Daily Check Up.

Clinical Focus