- PROFESSOR & CHAIR | Genetics and Genomic Sciences
- PROFESSOR | Psychiatry
- PROFESSOR | Neuroscience
Pamela Sklar is a neuroscientist, human geneticist and clinical psychiatrist investigating the genetic causes of psychiatric disorders, including schizophrenia and bipolar disorder. A major focus of her prior work has been to identify susceptibility genes for psychiatric diseases by applying tools developed for understanding and characterizing human sequence variation. Currently, she is Chair of the Department of Genetics and Genomic Sciences, and holds an endowed chair as Mount Sinai Professor of Psychiatric Genetics, and is a Professor of Genetics and Genomic Sciences.
Depression, Epigenetics, Genetics, Human Genetics and Genetic Disorders, Schizophrenia, Stem Cells, Synapses, Synaptic Plasticity, Synaptogenesis
Multi-Disciplinary Training Areas
Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
BA, St. John's College
MD, PhD, Johns Hopkins School of Medicine
The laboratory of psychiatric genomics will continue the long-standing basic research program of the PI to define the genetic architecture of the two most severe and heritable adult psychiatric disorders, BD and SCZ. Understanding the architecture requires knowing the number, frequency and effect size (and how they interact) of all the genetic risk factors and these would be undertaken in collaboration with members of the Genomics institute.
Studies are ongoing in the areas of:
1) large scale genome-wide association studies
2) rare variant identification by next generation sequencing
3) patient collection
4) genotype driven phenotyping
5) genetic risk prediction
6) biological follow-up of candidate genes
7) generation and study of pathways and biology in induced pluripotent stem cells from patients.
Division and Lab Website
http://research.mssm.edu/psychgenomics/ and http://research.mssm.edu/psychgenomics/sklar-lab/
Division of Psychiatric Genomics
Using as a foundation the superb basic and clinical resources of the Mount Sinai Medical Center we will build an infrastructure for improving the diagnosis and treatment of psychiatric diseases. The Division of Psychiatric Genetics and Genomics that includes a Laboratory of Psychiatric Genomics, a Laboratory of Molecular Analysis of Risk Genes for Psychiatric Disorders: SCZ (SCZ), Bipolar Disorder (BD), MDD and OCD, and a Laboratory of Translational Psychiatry.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr.Sklar did not report having any of the following types of financial relationships with industry during 2016 and/or 2017: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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