Michael S Breen, PhD Email Michael Breen
- ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Research in our laboratory aims to better understand the molecular factors underlying neurodevelopmental and neuropsychiatric disorders. We are specifically focused on two mechanistic-domains: 1) A-to-I RNA editing in the brain; and 2) immune mechanisms in the blood - both of which hold great promise for the development of actionable biomarkers and next generation theraputics. Our research studies generate functional genomic data sets (e.g. scRNA-seq, proteomics, metabolimics) from patient-derived tissues (e.g. peripheral blood, cord blood, postmortem brain tissue, iPSCs) using molecular biology and immunology tools, and subsequently analyze these data under a prism of computational and biostatistical methods. In doing so, we strive to construct biologically plausible mechanistic models of disease, for which we validate both functionally and clinically.
Autism, Computational Biology, Developmental Biology, Gene Discovery, Gene Regulation, Gene editing, Genetics, Genomics, Immunology, Inflammation, Neurobiology, Proteomics, Psychiatry, RNA, Schizophrenia, Systems Biology
PhD, University of Southampton
Postdoctoral Research Fellow, Ichan School of Medicine at Mount Sinai
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Dr.Breen did not report having any of the following types of financial relationships with industry during 2020 and/or 2021: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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