Allergy, Antigen Presentation, Cellular Immunity, Chemokines, Cytokines, Dendritic Cells, Epithelial Cells, Immunology, Inflammation, Knockout Mice, Mucosal Immunology, T Cells
Multi-Disciplinary Training Area
BSc(Hons), Queen's University
MSc, Queen's University
PhD, McMaster University
Postdoctoral, University of California, San Diego
Our laboratory is dedicated to understanding the mucosal immunology of food allergic disorders. Themes within this work include (1) understanding mechanisms responsible for development of sensitization and tolerance to food proteins, (2) determining how allergen-specific T cells home to the gut and induce disease, and (3) finding methods to modify the allergen-specific T cell response for therapeutic purposes. Much of our lab’s work to date has focused on the communication between gastrointestinal epithelial cells, dendritic cells, and antigen-specific T cells in the context of food allergy.
Sampson HA, Berin MC, Plaut M, Sicherer SH, Jones S, Burks AW, Lindblad R, Leung DY, Wood RA. The Consortium for Food Allergy Research (CoFAR) The First Generation. The Journal of allergy and clinical immunology 2018 Dec;.
Tordesillas L, Lozano-Ojalvo D, Dunkin D, Mondoulet L, Agudo J, Merad M, Sampson HA, Berin MC. PDL2 CD11b dermal dendritic cells capture topical antigen through hair follicles to prime LAP Tregs. Nature communications 2018 Dec; 9(1).
Tordesillas L, Berin MC. Mechanisms of Oral Tolerance. Clinical reviews in allergy & immunology 2018 Oct; 55(2).
Shan M, Carrillo J, Yeste A, Gutzeit C, Segura-Garzón D, Walland AC, Pybus M, Grasset EK, Yeiser JR, Matthews DB, van de Veen W, Comerma L, He B, Boonpiyathad T, Lee H, Blanco J, Osborne LC, Siracusa MC, Akdis M, Artis D, Mehandru S, Sampson HA, Berin MC, Chen K, Cerutti A. Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44. Immunity 2018 Sep;.
Benedé S, Cody E, Agashe C, Berin MC. Immune Characterization of Bone Marrow-Derived Models of Mucosal and Connective Tissue Mast Cells. Allergy, asthma & immunology research 2018 May; 10(3).
Berin MC, Grishin A, Masilamani M, Leung DY, Sicherer SH, Jones SM, Burks AW, Henning AK, Dawson P, Grabowska J, Agashe C, Davidson WF, Wood RA, Sampson HA. Egg-specific IgE and basophil activation but not egg-specific T-cell counts correlate with phenotypes of clinical egg allergy. The Journal of allergy and clinical immunology 2018 Mar;.
Tordesillas L, Berin MC. Mechanisms of Oral Tolerance. Clinical reviews in allergy & immunology 2018 Feb;.
Benedé S, Berin MC. Mast cell heterogeneity underlies different manifestations of food allergy in mice. PloS one 2018 Jan; 13(1).
Chiang D, Chen X, Jones SM, Wood RA, Sicherer SH, Burks AW, Leung DY, Agashe C, Grishin A, Dawson P, Davidson WF, Newman L, Sebra R, Merad M, Sampson HA, Losic B, Berin MC. Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector T2 subsets. The Journal of allergy and clinical immunology 2018 Jan;.
Dunkin D, Berin MC, Mondoulet L, Tobar S, Yeretssian G, Tordesillas L, Iuga A, Larcher T, Guillespie V, Benhamou PH, Colombel JF, Sampson HA. Epicutaneous Tolerance Induction to a Bystander Antigen Abrogates Colitis and Ileitis in Mice. Inflammatory bowel diseases 2017 Nov; 23(11).
Agashe C, Chiang D, Grishin A, Masilamani M, Jones SM, Wood RA, Sicherer SH, Burks AW, Leung DY, Dawson P, Sampson HA, Berin MC. Impact of granulocyte contamination on PBMC integrity of shipped blood samples: Implications for multi-center studies monitoring regulatory T cells. Journal of immunological methods 2017 Oct; 449.
Tordesillas L, Berin MC, Sampson HA. Immunology of Food Allergy. Immunity 2017 Jul; 47(1).
Goswami R, Blazquez AB, Kosoy R, Rahman A, Nowak-Węgrzyn A, Berin MC. Systemic innate immune activation in food protein-induced enterocolitis syndrome. The Journal of allergy and clinical immunology 2017 Jun; 139(6).
Jones SM, Sicherer SH, Burks AW, Leung DY, Lindblad RW, Dawson P, Henning AK, Berin MC, Chiang D, Vickery BP, Pesek RD, Cho CB, Davidson WF, Plaut M, Sampson HA, Wood RA. Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. The Journal of allergy and clinical immunology 2017 Apr; 139(4).
Kosoy R, Agashe C, Grishin A, Leung DY, Wood RA, Sicherer SH, Jones SM, Burks AW, Davidson WF, Lindblad RW, Dawson P, Merad M, Kidd BA, Dudley JT, Sampson HA, Berin MC. Transcriptional Profiling of Egg Allergy and Relationship to Disease Phenotype. PloS one 2016 Oct; 11(10).
Blázquez AB, Berin MC. Microbiome and food allergy. Translational research : the journal of laboratory and clinical medicine 2016 Sep;.
Tordesillas L, Rahman AH, Hartmann BM, Sampson HA, Berin MC. Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut. The Journal of allergy and clinical immunology 2016 Aug;.
Caubet JC, Bencharitiwong R, Ross A, Sampson HA, Berin MC, Nowak-Węgrzyn A. Humoral and cellular responses to casein in patients with food protein-induced enterocolitis to cow's milk. The Journal of allergy and clinical immunology 2016 Jul;.
Rahman AH, Tordesillas L, Berin MC. Heparin reduces nonspecific eosinophil staining artifacts in mass cytometry experiments. Cytometry. Part A : the journal of the International Society for Analytical Cytology 2016 Jun; 89(6).
Tordesillas L, Mondoulet L, Blazquez AB, Benhamou PH, Sampson HA, Berin MC. Epicutaneous immunotherapy induces gastrointestinal LAP(+) regulatory T cells and prevents food-induced anaphylaxis. The Journal of allergy and clinical immunology 2016 Jun;.
Benedé S, Blázquez AB, Chiang D, Tordesillas L, Berin MC. The rise of food allergy: Environmental factors and emerging treatments. EBioMedicine 2016 May; 7.
Rahman AH, Tordesillas L, Berin MC. Heparin reduces nonspecific eosinophil staining artifacts in mass cytometry experiments. Cytometry. Part A : the journal of the International Society for Analytical Cytology 2016 Apr;.
Tobar S, Tordesillas L, Berin MC. Triclosan promotes epicutaneous sensitization to peanut in mice. Clinical and translational allergy 2016 Apr; 6.
Berin MC, Shreffler WG. Mechanisms Underlying Induction of Tolerance to Foods. Immunology and allergy clinics of North America 2016 Feb; 36(1).
Gregory JA, Shepley-McTaggart A, Umpierrez M, Hurlburt BK, Maleki SJ, Sampson HA, Mayfield SP, Berin MC. Immunotherapy using algal-produced Ara h 1 core domain suppresses peanut allergy in mice. Plant biotechnology journal 2016 Jan;.
Järvinen KM, Westfall J, De Jesus M, Mantis NJ, Carroll JA, Metzger DW, Sampson HA, Berin MC. Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance. PloS one 2015 Dec; 10(12).
Berin MC. Pathogenesis of IgE-Mediated Food Allergy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2015 Jul;.
Chiang D, Berin MC. An Examination of Clinical and Immunologic Outcomes in Food Allergen Immunotherapy by Route of Administration. Current allergy and asthma reports 2015 Jun; 15(6).
Berin MC. Immunopathophysiology of food protein-induced enterocolitis syndrome. The Journal of allergy and clinical immunology 2015 Mar;.
Järvinen KM, Suárez-Fariñas M, Savilahti E, Sampson HA, Berin MC. Immune factors in breast milk related to infant milk allergy are independent of maternal atopy. The Journal of allergy and clinical immunology 2014 Dec;.
Tordesillas L, Goswami R, Benede S, Grishina G, Dunkin D, Jarvinen KM, Maleki SJ, Sampson HA, Berin MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. The Journal of clinical investigation 2014 Oct;.
Mathern DR, Laitman LE, Hovhannisyan Z, Dunkin D, Farsio S, Malik TJ, Roda G, Chitre A, Iuga AC, Yeretssian G, Berin MC, Dahan S. Mouse and human Notch-1 regulate mucosal immune responses. Mucosal immunology 2014 Jul; 7(4).
Leonard SA, Martos G, Wang W, Nowak-Węgrzyn A, Berin MC. Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa. The Journal of allergy and clinical immunology 2012 Jun; 129(6).
Berin MC, Wang W. Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity. Mucosal immunology 2012 Jun;.
Berin MC, Sicherer S. Food allergy: mechanisms and therapeutics. Current opinion in immunology 2011 Dec; 23(6).
Dunkin D, Berin MC, Mayer L. Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. The Journal of allergy and clinical immunology 2011 Dec; 128(6).
Blázquez AB, Mayer L, Berin MC. Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance. Gastroenterology 2010 Oct; 139(4).
Blázquez AB, Knight AK, Getachew H, Bromberg JS, Lira SA, Mayer L, Berin MC. A functional role for CCR6 on proallergic T cells in the gastrointestinal tract. Gastroenterology 2010 Jan; 138(1).
Berin MC, Mayer L. Immunophysiology of experimental food allergy. Mucosal immunology 2009 Jan; 2(1).
Berin MC, Shreffler WG. T(H)2 adjuvants: implications for food allergy. The Journal of allergy and clinical immunology 2008 Jun; 121(6).
Blázquez AB, Berin MC. Gastrointestinal dendritic cells promote Th2 skewing via OX40L. Journal of immunology (Baltimore, Md. : 1950) 2008 Apr; 180(7).
Li H, Chehade M, Liu W, Xiong H, Mayer L, Berin MC. Allergen-IgE complexes trigger CD23-dependent CCL20 release from human intestinal epithelial cells. Gastroenterology 2007 Dec; 133(6).
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