Fibrosis, Inflammation, Multiple Sclerosis, Muscular Dystrophy
MD, Fudan University Shanghai Medical College
PhD, University of Cincinnati
Internship, Internal Medicine
Wayne State University
Wayne State University
Johns Hopkins Hospital
Chinese (Mandarin), Chinese (Shanghai), English
Roles of chemokines and chemokine receptors in Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is the most common, lethal, and currently untreatable genetic muscle disease. Muscle pathology of DMD is featured by chronic inflammation and fibrosis, which directly lead to muscle dysfunction and clinical muscle weakness. Ameliorating muscle inflammation and fibrosis may thus represent a viable therapeutic approach for DMD. The chemokine system plays a key role in recruiting inflammatory cells and profibrogenic cells into injured muscles. This research is to determine the roles of the chemokine system in inflammation and fibrosis associated with DMD and to explore the possibility of modifying inflammation, reducing fibrosis, and improving muscle function by altering the expression and function of related chemokines and chemokine receptors. The DMD mouse models and relevant chemokine or chemokine receptor knockout mouse models are being used for the study.
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Dr.Zhou did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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