Photo of Kenan Onel

Kenan Onel, MD, PhD

Cancer (Oncology)
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Mount Sinai Doctors ?
    • Positions
    • PROFESSOR | Genetics and Genomic Sciences
    • PROFESSOR | Pediatrics, Hematology/Oncology
    • PROFESSOR | Pathology, Molecular and Cell Based Medicine
    • PROFESSOR | Medicine, Hematology and Medical Oncology
    • Specialties
    • Cancer (Oncology)
    • Genetics and Genomics
    • Pediatric Hematology-Oncology
    • Language
    • English
    • Hospital Affiliations
    • Mount Sinai Brooklyn
    • Mount Sinai Beth Israel
    • The Mount Sinai Hospital
    • Mount Sinai Queens
    • Mount Sinai Morningside and Mount Sinai West

Dr. Kenan Onel is known internationally for his work on hereditary cancer and is recognized as a leader in functional genomics, which integrates genetic and laboratory investigations, leading to new insights into human health and disease. As Director of the Center for Cancer Prevention and Wellness and Associate Director of Clinical Cancer Genetics and Precision Oncology at The Tisch Cancer Institute at Mount Sinai, Dr. Onel heads a program that provides services for patients and families at high risk of cancer through lifelong preventive care and surveillance. The program offers genetic counseling and testing in blood relatives of individuals who have specific genetic mutations and extends ongoing personalized care for at-risk family members. The goal is to ensure optimal health and wellness, and prevent development of cancer when possible.

During a lengthy tenure at the UChicago Medicine, Dr. Onel was Director of the Familial Cancer Clinic. Prior to joining Mount Sinai in 2019, Dr. Onel was Chief of Medical Genetics and Human Genomics at Northwell Health. Dr. Onel earned his MD and PhD in Molecular Genetics from the Tri-Institutional MD-PhD Program (Weill Cornell Medicine, The Rockefeller University, and Memorial Sloan Kettering Cancer Center). He completed residency training in Pediatrics at NewYork-Presbyterian Hospital/Columbia University Medical Center and a fellowship in Pediatric Hematology/Oncology at Memorial Sloan Kettering Cancer Center.

Center for Cancer Prevention and Wellness

The Center for Cancer Prevention and Wellness is a one-of-a-kind, integrated hereditary cancer care center applying genetic medicine to identify patients at risk for cancer and providing them and their families with lifelong, preventative care and surveillance, empowering patients, families, and research.

While most cancers are caused by a combination of genetic factors, environmental factors, and other factors still unknown, some cancers result from an inherited predisposition. Commonly, individuals do not know of their predisposition until a family member is diagnosed with cancer.
Despite the link between genetics and cancer risk, only a small number of centers consider genetic factors in their evaluation of patients with the disease. Of those that do, most cancer risk programs live in the land of cancer and are almost completely unlinked to prevention. At Mount Sinai, we aim to rewrite the rules by returning cancer prevention to the place where it belongs – the land of wellness.

The Center’s primary objective is to provide families with a “wellness home.”

That is, a safety net for patients and their families, with ongoing medical surveillance and the promotion of wellness. The Center’s Genetic Counselors and their multidisciplinary team will provide the resources each patient needs to receive effective, expert care and ongoing surveillance—all within the Mount Sinai Health System.

The Center’s novel approach to cancer prevention is through the Pivot to Wellness program:

The program brings together Mount Sinai’s expertise in genetics, primary care, and specialty care, melding all the resources a family needs to attain or maintain wellness. By leveraging the strength of the Mount Sinai Health System in the service of cancer prevention, we help patients and families take charge of their personal cancer risk - all in a concerted effort to empower each and every individual to get well, stay well, and be well.


Pediatric Hematology & Oncology


MD,PHD, Cornell Medical Center

Residency, Pediatrics
New York Presbyterian Hospital

Fellowship, Pediatric Hematology/Oncology
New York Presbyterian Hospital