Julius Hedden III, PhD Email Julius Hedden III
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- Positions
- ASSOCIATE PROFESSOR | Neurology
- ASSOCIATE PROFESSOR | Neuroscience
- ASSOCIATE PROFESSOR | Diagnostic, Molecular and Interventional Radiology
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- Language
- English
Dr. Hedden's research examines individual variation across neural systems that indicate vulnerability to aging processes, with the aim of understanding why some older adults will age gracefully while others will face impairment of these systems due to neurodegeneration, including preclinical Alzheimer’s disease and cerebrovascular disease. By applying advanced imaging tools and neuropsychological tests to identify individuals likely to face neurodegeneration, we can create and improve personalized diagnosis and intervention regimens that present the best opportunity to arrest neurodegeneration before damage leading to dementia occurs.
As Director of Neuroimaging and Biomarker Research in Aging and Alzheimer’s Disease at Mount Sinai and as the Core Lead of the Biomarker Core for the Alzheimer's Disease Research Center at Mount Sinai, he collaborates with colleagues in the Biomedical Engineering and Imaging Institute, the Ronald M. Loeb Center for Alzheimer’s Disease, in the Neurology, Radiology, and Neuroscience departments, and across institutions to accelerate advanced imaging research on aging and neurodegenerative diseases.
To learn more about research and career opportunities in the laboratory, please see: http://labs.icahn.mssm.edu/heddenlab/.
Research Topic
Aging, Alzheimer's Disease, Brain, Brain Imaging, Cerebral Cortex, Cognitive Neuroscience, Diffusion Tensor Imaging, Hippocampus, MRI, Magnetic Resonance Imaging, Memory, Neuroscience, Positron Emission Tomography, Prefrontal Cortex
Multi-Disciplinary Training Area
Neuroscience [NEU]
Language
English
Role of Age, Dopamine, and Tau Related Network Disruption in Setting a Context for Progression Toward Alzheimer's Disease
This project investigates the impact of tau associated with Alzheimer’s disease and of dopaminergic changes in aging on the function of brain networks and associated cognitive abilities. Cognitively normal older adults and individuals diagnosed with Mild Cognitive Impairment undergo MR-PET imaging to measure dopamine and tau levels in the brain, which are examined for relationships to the organization and function of brain networks. To get volunteer for any of these projects, please contact Jacqueline Emerson, Clinical Research Coordinator: Jacqueline.emerson@mssm.edu.
Tau, Amyloid, & White Matter Burden Interact to Impact Brain Networks in Preclinical Alzheimer’s disease
This project investigates the regional impact of tau and amyloid associated with Alzheimer’s disease and of white matter damage of presumed vascular origin on the function of brain networks and associated cognitive abilities. We use MR-PET imaging to measure amyloid and tau in the brains of cognitively normal older adults and examine relationships to the architecture of brain networks that undergird cognitive function.
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Dr.Hedden III did not report having any of the following types of financial relationships with industry during 2021 and/or 2022: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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