Joseph M Castellano, PhD Email Joseph Castellano
- ASSISTANT PROFESSOR | Neuroscience
- ASSISTANT PROFESSOR | Neurology
As a graduate student, Dr. Castellano studied how the strongest genetic risk factor for Alzheimer's disease influences metabolism of the pathogenic peptide amyloid beta from brain interstitial fluid. In David Holtzman’s group, he used in vivo microdialysis to show in behaving mice that clearance of this peptide is impeded by the presence of APOE4, whereas clearance in the context of more inert or protective forms is faster. As he transititoned into postdoctoral training, Dr. Castellano became fascinated by the possibility that brain function may be, in part, shaped by the immune system and by unexplored activities present within circulation. In postdoctoral work with Tony Wyss-Coray, Dr. Castellano sought to identify and characterize factors in the periphery that reverse features of brain aging, finding that systemic treatment with umbilical cord plasma revitalizes hippocampal function in aged mice. The Castellano laboratory now focuses on characterizing the activity of proteins, including TIMP2, and their action in mediating long-range effects on circuits in the brain in the context of Alzheimer's disease and other disorders.
Aging, Alzheimer's Disease, Blood-Brain Barrier, Epigenetics, Extracellular Matrix, Hippocampus, Immunology, Memory, Microglia, Neuro-degeneration/protection, Neuroscience, Synaptic Plasticity, Transgenic Mice
Multi-Disciplinary Training Area
PhD, Washington University in St. Louis
Postdoctoral Fellowship, Stanford University
Katz and Martin 2018 Friedman Brain Institute Research Scholar
K99/R00 Pathway to Independence Award
New Vision Award
Donor's Cure/Charleston Conference on AD
Jane Coffin Childs Postdoctoral Fellowship
Postdoctoral Ruth L. Kirschstein National Research Service Award (awarded)
Child Health Research Institute Postdoctoral Grant
Stanford Dean’s Postdoctoral Fellowship (awarded)
34th Annual James L. O'Leary Prize for Research in Neuroscience
Washington University School of Medicine
Predoctoral Ruth L. Kirschstein National Research Service Award
Phi Beta Kappa
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Castellano during 2021 and/or 2022. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Alkahest, Inc.
Other activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
- Alkahest, Inc.
- Alkahest, Inc.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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