James Murrough, MD Email James Murrough
- ASSOCIATE PROFESSOR | Psychiatry
- ASSOCIATE PROFESSOR | Neuroscience
- Hospital Affiliation
- The Mount Sinai Hospital
- Physician Office 212-241-7574212-241-7574
Dr. James Murrough is Associate Professor of Psychiatry and Neuroscience and Director of the Depression and Anxiety Center for Discovery and Treatment at the Icahn School of Medicine at Mount Sinai. He is a Faculty member of the Friedman Brain Institute and a Primary Principal Investigator of the Center of Excellence in Neuropharmacology, both components of the Icahn School of Medicine. Dr. Murrough conducts clinical and translational research aimed at understanding the biological basis of mood and anxiety disorders in order to point the way towards new, more effective treatments. He received his Bachelor of Science in Neuroscience and Behavioral Biology from Emory University in Atlanta and his Medical degree from Tufts University School of Medicine in Boston. He completed his residency training in Psychiatry at Mount Sinai and a research fellowship in experimental therapeutics and clinical neuroscience in mood disorders, also at Mount Sinai. He obtained a PhD in clinical research methodology and biostatistics from Mount Sinai as part of a Career Development Award from the National Institute of Mental Health. Dr. Murrough has received research support from the National Institutes of Health, the Doris Duke Charitable Foundation, the American Foundation for Suicide Prevention, the Dana Foundation and the Brain and Behavior Research Foundation. He is a Member of the American College of Neuropsychopharmacology and an active member of the scientific community. In addition to his research and educational activities, Dr. Murrough maintains an active clinical practice focusing on evidence-based pharmacological treatments for mood and anxiety disorders.
Key Words: depression, anxiety, bipolar disorder, post traumatic stress disorder, psychopharmacology, antidepressants, neuroimaging
Financial & Billing Information
Please direct any detailed billing or financial inquires to the Mount Sinai Psychiatry billing customer service number at 212-659-8752.
Psychiatry, American Board of Psychiatry and Neurology
- Panic Disorder
- Post-Traumatic Stress Disorder
- Social Anxiety Disorder
- Specific Phobias
Depression, Neuropeptides, Neurophysiology, Neuroscience, Neurotransmitters, Neurotrophins, Patient Centered Outcomes Research, Psychiatry
Mount Sinai Hospital
Murrough JW, Mathew SJ. Overcoming antidepressant treatment resistance: focus on glutamate. Modern Trends in Pharmacopsychiatry; 27.
Murrough JW, Mathew SJ. Neurochemical Imaging in Anxiety Disorders. Neuropsychiatric Imaging;.
Murrough JW, Mao X, Collins KA, Kelly C, Andrade G, Nestadt P, Levine SM, Mathew SJ, Shungu DC. Increased Ventricular Cerebrospinal Fluid Lactate in Chronic Fatigue Syndrome. Part II: Comparison with Major Depressive Disorder by 1H MRS at 3.0 Tesla. NMR Biomedicine 2010; 23: 643-650.
Murrough JW, Henry S, Hu J, Gallezot JD, Planeta-Wilson B, Neumaier JF, Neumeister A. Reduced ventral striatal/ventral pallidal serotonin(1B) receptor binding potential in major depressive disorder. Psychopharmacology (Berl) 2010 May;.
aan het Rot M, Collins KA, Murrough JW, Perez A, Reich DL, Charney DS, Mathew SJ. Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression. Biol Psychiatry 2010; 67: 139-145.
Mathew SJ, Murrough JW, aan het Rot M, Collins KA, Garakani A, Reich DL, Charney DS. Riluzole for Relapse Prevention Following Intravenous Ketamine in Treatment-Resistant Depression: A Pilot Randomized, Placebo-Controlled Study. Int J Neuropsychopharm 2010; 13: 71-82.
New AS, Fan J, Murrough JW, Liu X, Liebman RE, Guise KG, Tang CY, Charney DS. An Functional Magnetic Resonance Imaging Study of Deliberate Emotion Regulation in Resilience and Posttraumatic Stress Disorder. Biol. Psychiatry 2009; 66: 656-664.
Price RB, Shungu DC, Mao X, Nestadt P, Kelly C, Collins KA, Murrough JW, Charney DS, Mathew SJ. Amino Acid Neurotransmitters in the Occipital and Anterior Cingulate Cortices: Relationship to Treatment-Resistance in Major Depressive Disorder. Biol Psychiatry 2009; 65: 792-800.
Epstein J, Pan H, Kocsis JH, Yang Y, Butler T, Chusid J, Hochberg H, Murrough J, Strohmayer E, Stern E, Silbersweig DA. Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects. Am J Psychiatry 2006; 163: 1784-1790.
Murrough JW, Boss-Williams KA, Emery MS, Bonsall RW, Weiss JM. Depletion of Brain Norepinephrine Does Not Reduce Spontaneous Ambulatory Activity of Rats in the Home Cage. Brain Res 2000; 883: 125-130.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Murrough during 2018 and/or 2019. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- Impel NeuroPharma
- ProPhase, LLC
Scientific Advisory Board:
- Genentech, Inc.
- Janssen Pharmaceuticals, Inc.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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