Ian S Maze, PhD Email Ian Maze
- ASSOCIATE PROFESSOR | Neuroscience
- ASSOCIATE PROFESSOR | Pharmacological Sciences
Ian S. Maze, Ph.D., is a neurobiologist with extensive training in the molecular biology and chromatin biochemistry of histone regulation in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease.
Addiction, Behavior, Chromatin, Depression, Drug Design and Discovery, Gene Expressions, Molecular Biology, Neuroscience
Multi-Disciplinary Training Areas
Development, Regeneration, and Stem Cells [DRS], Neuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
BS, The Ohio State University
PhD, Mount Sinai School of Medicine
Postdoctoral Fellowship, The Rockefeller University
Dr. Harold and Golden Laport Basic Research Award
Winner of Presidential Early Career Award for Scientists and Engineers (PECASE)
ACNP Travel Award
MQ: Transforming Mental Health Research Fellowship Award
NARSAD Young Investigator Award
Terry A. Krulwich Dissertation Award, Mount Sinai School of Medicine
The Maze laboratory is focused on understanding the role of chromatin dynamics, nucleosomal turnover and histone variant exchange in the central nervous system during periods of transcriptional, synaptic and behavioral plasticity. Extended emphasis is placed on investigating the functions of novel neuronal specific/enriched histone modifications and ‘reader’ proteins, as well as their role in developmental neurological disorders (e.g. Down syndrome) and adult psychiatric illness. Current projects include the utilization of chromatin biochemical techniques, genome-wide sequencing analyses and viral vector-based gene modification systems to investigate novel histone-based mechanisms of monoaminergic dysfunction in major depressive disorder. Search PubMed for publications
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Dr.Maze did not report having any of the following types of financial relationships with industry during 2020 and/or 2021: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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