Hideki Ueno, M.D, Ph.D. is a Professor at Global Health and Emerging Pathogens Institute and Department of Microbiology. Dr. Ueno has more than 15 years of experience on immunology research with primary human cells. His research focuses on the studies on the adaptive immune system in humans, the major immunological protection mechanism in charge of generation and maintenance of antigen-specific immune response.
The Ueno Lab webpage: http://labs.icahn.mssm.edu/uenolab/
Autoimmunity, B Cells, Cellular Differentiation, Cellular Immunity, Cytokines, Dendritic Cells, Immunology, Infectious Disease, Inflammation, Influenza Virus, Lymphocytes, Molecular Biology, Neuroscience, T Cells
Multi-Disciplinary Training Areas
Immunology [IMM], Microbiology [MIC]
MD, Kyoto University
PhD, Graduate School of Medicine, Kyoto University
Post-doctoral fellow, Baylor Institute for Immunology Research
Pathogenic CD4+ T cells in Human Neuroinflammatory Diseases
Depletion of B cells is effective to treat patients with neuromyelitis optica (NMO) and multiple sclerosis (MS), but the immune mechanism remains unclear. We are interested in how B cell depletion affects the antigen-specific CD4+ T cell repertoires in patients. Towards this goal, we are currently developing a new assay that permits the detection of antigen-specific T cells with superior sensitivity and specificity to currently available assays.
T Follicular Helper Cells in Human Autoimmunity
Tfh cells play a major pathogenic role in Systemic Lupus Erythematosus (SLE). However, the precise mechanism remains largely obscure. We are aiming at identifying the feature of pathogenic Tfh cells unique to SLE, and determining how the pathogenic Tfh cells contribute to altered B cell responses in patients with SLE.
Basic Science on Human T follicular helper cells
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for providing help to B cells. Dysregulation of Tfh responses are associated with autoimmunity (when excessive) and with poor antibody response (when insufficient). My lab aims to identify the molecules and pathways controlling human Tfh responses.
Immune Mechanisms Associated with Protective Ab Response for Influenza
While both vaccination and infection induce Tfh and antibody response, the magnitude and the quality of Tfh responses are radically different. Our previous studies show that seasonal influenza vaccination induces antibody response by activating a specific Tfh subset, called Tfh1 cells, together with influenza-specific memory B cells in humans. We aim to define the fundamental biological differences on memory Tfh cells generated by influenza infection and vaccination, and determine the key molecules and pathways associated with long-lived memory Tfh cells in humans.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Ueno during 2020 and/or 2021. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- NapaJen Inc.
Other activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
- Astellas Pharma Inc.
- Japan Agency for Medical Research and Development
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