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Gareth R John, PhD Email Gareth John

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The John Laboratory (Beker Multiple Sclerosis Research Laboratory) is part of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis, the Department of Neurology, and the Friedman Brain Institute. Our research focuses on identifying novel avenues to restrict tissue damage and promote repair in inflammatory and demyelinating CNS conditions, notably multiple sclerosis (MS), neuromyelitis optica (NMO), and viral encephalitis. MS is the most common non-traumatic cause of paralysis in young adults in the US and Europe, the symptoms of which are driven by autoimmune demyelination of CNS white matter, while NMO is a rare but aggressive autoimmune MS-like condition characterized by spinal cord and optic nerve lesions, paralysis, and blindness.

Our research aims to understand the mechanisms underlying lesion pathogenesis and repair in these conditions, and focuses on how the environment within the CNS controls inflammatory lesion size and the potential for repair. We make extensive use of conditional genetic models in which developmental myelin formation, and demyelination and remyelination in adults, are accelerated or impaired. Phenotypes in conditional knockout models developed in the lab are then interrogated using genome-scale analyses of transcription and chromatin occupancy, confocal imaging, and electron microscopy. The goal of this work is to identify novel therapies to prevent lesion formation and protect patient health, and to repair existing damage and promote return of function. Our research is funded by the National Institutes of Health, the National MS Society, the Guthy-Jackson Foundation, pharmaceutical and biotech industry collaborations, and private benefactors.

Team members:
Gareth John VetMB PhD Professor
Sam Horng, MD PhD Assistant Professor Leon Levy Scholar
Candice Chapouly PhD Postdoctoral Fellow
Ari Dienel, PhD Postdoctoral Fellow
Setsu Sawai MD PhD Postdoctoral Fellow
Chi Zhang, PhD Postdoctoral Fellow
Ben Laitman BA MSTP Student NINDS F30 Scholar
John Mariani BA PhD Student
Anthony Therattil BA Research Technician.

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Research Topic

Brain, Cytokines, Demyelination, Immunology, Inflammation, Multiple Sclerosis, Myelination, Neurobiology, Regeneration

Multi-Disciplinary Training Area

Neuroscience [NEU]