Eirini Papapetrou, MD, PhD Email Eirini Papapetrou
- ASSOCIATE PROFESSOR | Oncological Sciences
- ASSOCIATE PROFESSOR | Medicine, Hematology and Medical Oncology
Eirini Papapetrou studies blood disorders, particularly myeloid malignancies, with human pluripotent stem cells. Her lab developed the first iPSC models of Myelodysplastic Syndromes and Acute Myeloid Leukemia. The Papapetrou lab combines expertise in induced pluripotent stem (iPS) cell generation, genome editing (CRISPR) and hematopoiesis.
Cancer Genetics, Hematopoiesis, Stem Cells
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development, Regeneration, and Stem Cells [DRS], Genetics and Data Science [GDS]
MD, University of Patras, Greece
PhD, University of Patras, Greece
Postdoctoral, Memorial Sloan-Kettering Cancer Center
Tito Bastianello Young Investigator Award
MDS International Foundation
American Society for Clinical Investigation Young Physician-Scientist Award
American Society for Clinical Investigation (ASCI)
American Society of Hematology (ASH) Junior Faculty Scholar Award
American Society of Hematology (ASH)
Sidney Kimmel Foundation Scholar Award
Sidney Kimmel Foundation for Cancer Research
Aplastic Anemia & MDS IF Research Grant Award
Aplastic Anemia & MDS International Foundation
John H. Tietze Stem Cell Scientist Award
Ellison Medical Foundation New Scholar in Aging Award
Ellison Medical Foundation
Damon Runyon-Rachleff Innovation Award
Damon Runyon Cancer Research Foundation
UW Royalty Research Fund Award
University of Washington
K99/R00 Pathway to Independence Award
Cellular alchemy meets genome engineering
We use human pluripotent stem cells to understand the mechanisms of malignant and non-malignant blood diseases and to develop new therapies. We are harnessing somatic cell reprogramming and genetic engineering technologies to develop new models of normal and abnormal hematopoiesis. By capturing and introducing disease-associated genetic mutations and large chromosomal deletions in patient-derived induced pluripotent stem cells (iPSCs) we study their phenotypic and functional consequences, attempt to reconstruct the genetic history of leukemia progression and seek to identify new therapeutic targets through genetic screens.
Genotype-driven modeling of Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are clonal hematologic disorders characterized by ineffective hematopoiesis - manifested as peripheral blood cytopenia and dysplastic bone marrow (BM) - and a propensity for progression to BM failure or acute myeloid leukemia (AML) with poor prognosis. Although relatively common diseases, their pathogenesis is poorly understood.
We have recently established iPSC models of MDS that offer exciting new possibilities for the study of the molecular pathogenesis of MDS and the investigation of its genetics, clonal evolution and progression to leukemia and can provide a powerful platform for phenotype-based genetic and chemical screens to identify new therapeutic targets. We have also developed new strategies, combining AAV-mediated gene targeting with modified Cre-lox technology, as well as with the Cas9-CRISPR system, to engineer targeted chromosomal deletions in human iPSCs. These offer new opportunities to interrogate the functional consequences of large copy number variants associated with human cancer.
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Dr. Papapetrou has not yet completed reporting of Industry relationships.
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