- ASSISTANT PROFESSOR Medicine, Nephrology
MD, Duke University
BA, Duke University
MS, Columbia University
Mailman School of Public Health
Residency, Internal Medicine
Mount Sinai Hospital
Mount Sinai Hospital
ResearchClinical and research interests focus on acute and chronic kidney disease in patients with HIV and hepatitis C. Ongoing projects include a prospective research cohort in Mount Sinai's active HIV practice, as well as two studies investigating the utility of currently available GFR estimates in patients with HIV infection. Study objectives in the HIV cohort include description of the prevalence, incidence, and predictors of acute and chronic kidney disease in the era of antiretroviral therapy, as well as improved understanding of the impact of HCV co-infection on the risk for kidney disease.
Wyatt CM, Malvestutto C, Coca SG, Klotman PE, Parikh CR. The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis. AIDS (London, England) 2008 Sep; 22(14).
Wyatt CM, Morgello S, Katz-Malamed R, Wei C, Klotman ME, Klotman PE, D'Agati VD. The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy. Kidney international 2009 Feb; 75(4).
Paragas N, Nickolas TL, Wyatt C, Forster CS, Sise M, Morgello S, Jagla B, Buchen C, Stella P, Sanna-Cherchi S, Carnevali ML, Mattei S, Bovino A, Argentiero L, Magnano A, Devarajan P, Schmidt-Ott KM, Allegri L, Klotman P, D'Agati V, Gharavi AG, Barasch J. Urinary NGAL marks cystic disease in HIV-associated nephropathy. Journal of the American Society of Nephrology : JASN 2009 Aug; 20(8).
Wyatt CM, Hoover DR, Shi Q, Seaberg E, Wei C, Tien PC, Karim R, Lazar J, Young MA, Cohen MH, Klotman PE, Anastos K. Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. Journal of acquired immune deficiency syndromes (1999) 2010 Sep; 55(1).
Wyatt CM, Shi Q, Novak JE, Hoover DR, Szczech L, Mugabo JS, Binagwaho A, Cohen M, Mutimura E, Anastos K. Prevalence of kidney disease in HIV-infected and uninfected Rwandan women. PloS one 2011; 6(3).
Wyatt CM, Hoover DR, Shi Q, Tien PC, Karim R, Cohen MH, Goderre JL, Seaberg EC, Lazar J, Young MA, Klotman PE, Anastos K. Pre-existing albuminuria predicts AIDS and non-AIDS mortality in women initiating antiretroviral therapy. Antiviral therapy 2011; 16(4).
Jao J, Palmer D, Leus I, Tih P, Baweja M, Klotman M, Sperling R, Wyatt C. Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011 Sep; 26(9).
Medapalli RK, Parikh CR, Gordon K, Brown ST, Butt AA, Gibert CL, Rimland D, Rodriguez-Barradas MC, Chang CC, Justice AC, He JC, Wyatt CM. Comorbid diabetes and the risk of progressive chronic kidney disease in HIV-infected adults: data from the Veterans Aging Cohort Study. Journal of acquired immune deficiency syndromes (1999) 2012 Aug; 60(4).
Mocroft A, Neuhaus J, Peters L, Ryom L, Bickel M, Grint D, Koirala J, Szymczak A, Lundgren J, Ross MJ, Wyatt CM. Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults. PloS one 2012; 7(7).
Inker LA, Wyatt C, Creamer R, Hellinger J, Hotta M, Leppo M, Levey AS, Okparavero A, Graham H, Savage K, Schmid CH, Tighiouart H, Wallach F, Krishnasami Z. Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals. Journal of acquired immune deficiency syndromes (1999) 2012 Nov; 61(3).
Hotta MT, Broderick E, Wyatt CM. Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy. AIDS (London, England) 2013 Jul; 27(11).
Estrella MM, Wyatt CM, Pearce CL, Li M, Shlipak MG, Aouizerat BE, Gustafson D, Cohen MH, Gange SJ, Kao WH, Parekh RS. Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney international 2013 Oct; 84(4).
Wyatt CM, Schwartz GJ, Owino Ong'or W, Abuya J, Abraham AG, Mboku C, M'mene LB, Koima WJ, Hotta M, Maier P, Klotman PE, Wools-Kaloustian K. Estimating kidney function in HIV-infected adults in Kenya: comparison to a direct measure of glomerular filtration rate by iohexol clearance. PloS one 2013; 8(8).
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Wyatt during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Other Activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership.
- BioCryst Pharmaceuticals, Inc.; Bristol-Myers Squibb
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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