Bo Chen, PhD Email Bo Chen
- SENIOR FACULTY | Ophthalmology
- SENIOR FACULTY | Cell, Developmental & Regenerative Biology
- SENIOR FACULTY | Neuroscience
Axonal Growth and Degeneration, Neuro-degeneration/protection, Neuronal Regeneration, Neuroscience
PhD, University of Miami
Postdoc, Harvard Medical School
Pew Scholar in the Biomedical Sciences
The Pew Charitable Trusts
Neural Degeneration and Regeneration in the Mammalian Retina
We are currently recruiting motivated postdoctoral researchers and students to join our research adventures. The main research interests of my laboratory focus on the mechanistic and therapeutic studies of neurodegenerative diseases in the retina resulting in vision impairment and blindness. We study signaling pathways and gene expression network in retinal neurons in normal and diseased conditions, with an ultimate aim to save vision. Neuroprotection and neuroregeneration are the two main strategies we use to prevent the death of existing neurons or to generate new neurons. 1. For neuroprotection, we investigate molecular mechanisms underlying the degeneration of photoreceptors, the primary sensory neurons that mediate the first step in vision, and ganglion cells, the output neurons of the retina. An in-depth understanding the signaling pathways that are perturbed in a diseased retina will facilitate the design of therapeutic strategies to protect photoreceptors and ganglion cells through modulation of the components of the affected pathways. 2. For neural regeneration, we examine the intrinsic signaling pathways and transcription control in Müller glial cells, the primary glial cell type in the retina, in order to reprogram them in vivo to generate adult retinal stem cells that are capable of differentiating to retinal neurons. 3. In addition, my laboratory is also actively exploring strategies to promote axon regeneration using optic nerve crush to model CNS (central nervous system) injury.
Yao K, Qiu S, Wang YV, Park SJ, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature 2018 Aug;.
Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell reports 2016 09; 17(1).
Guo X, Snider WD, Chen B. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. eLife 2016 Mar; 5.
Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa. Nature communications 2015 Aug; 6.
Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, De Camilli P. Coupling between endocytosis and sphingosine kinase 1 recruitment. Nature cell biology 2014 Jul; 16(7).
Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proceedings of the National Academy of Sciences of the United States of America 2011 Sep; 108(37).
Chen B, Cepko CL. HDAC4 regulates neuronal survival in normal and diseased retinas. Science (New York, N.Y.) 2009 Jan; 323(5911).
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Dr.Chen did not report having any of the following types of financial relationships with industry during 2017 and/or 2018: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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