Benjamin D Greenbaum, PhD Email Benjamin Greenbaum
- ASSOCIATE PROFESSOR | Medicine, Hematology and Medical Oncology
- ASSOCIATE PROFESSOR | Pathology, Molecular and Cell Based Medicine
- ASSOCIATE PROFESSOR | Oncological Sciences
I am a theoretical physicist working in quantitative biology at the intersection of cancer research, immunology, evolutionary theory, and virology. I currently collaborate with the Icahn Institute for Data Science and Genomic Technology. Our lab uses tools from physics, mathematics and computer science to better understand how self versus non-self discrimination occurs and the role such discrimination plays in the evolution of tumors and viruses. Previously, we showed how single-stranded RNA viruses evolve to mimic the genomic environment of their hosts. We found that the original 1918 influenza lineage altered its genome to mimic nucleotide motif composition features of the human genome, likely to evade targeting of those motifs by innate immune receptors, and found that such host genome mimicry is a generic feature of many viruses.
The significance of the immune mechanisms in cancer has recently become fully appreciated. As a result we working on several topics related to immunotherapy and cancer immunology. We are studying the role of the immune system in several cancers, particularly the interaction of host tumoral RNA with the innate immune system, the role of neoantigens in the evolution of tumors both generally and in response to therapy, and the role of endogenous and exogenous viruses in cancer. In addition to shedding light on these scientific issues, we are working to translate our work into clinically impactful results in cancer immunotherapy. At the same time we continue to develop theoretical approaches to a variety of fundamental problems in host and viral genome evolution.
For publications see:
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PhD, Columbia University
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Greenbaum during 2019 and/or 2020. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- Rome Therapeutics, Inc
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Rome Therapeutics, Inc.
Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose
- Bristol-Myers Squibb
- Rome Therapeutics
- Rome Therapeutics, Inc
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