Avner Schlessinger, PhD Email Avner Schlessinger
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- Position
- ASSOCIATE PROFESSOR | Pharmacological Sciences
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- Language
- English
Dr. Avner Schlessinger is an Associate Professor of Pharmacological Sciences at the Icahn School of Medicine at Mount Sinai in New York City, an Associate Director of Mt. Sinai Center for Therapeutics Discovery, and Co-Director of the Pharmacology, Discovery and Therapeutics Training Area. Dr. Schlessinger graduated from Tel Aviv University with a BSc in Biology and Chemistry, and completed his PhD from Columbia University in the Department of Biochemistry and Molecular Biophysics. As a PhD student, he developed programs predicting protein structure and function using various machine-learning approaches such as artificial neural networks. Following his graduate studies, Dr. Schlessinger was an NIH NRSA postdoctoral fellow at the Department of Bioengineering and Therapeutic Sciences at UCSF, where he established methods for computer-aided drug design and used these approaches to rationally design tool compounds for membrane proteins. The overall goal of Dr. Schlessinger’s lab is to improve and automate the drug discovery process by integrating approaches in computational chemistry and bioinformatics, and applying these methods to characterize disease pathways. His lab publishes in the areas of chemical biology, bioinformatics, and drug discovery, as well as in personalized medicine and pharmacogenomics. Dr. Schlessinger serves on the Editorial Boards of PLOS Computational Biology and Journal of General Physiology, as well as on the Advisory Board of various biotechnology companies and international consortia.
Research Topics
Cancer, Computational Biology, Drug Design and Discovery, Membrane Proteins/Channels, Protein Structure/Function, Transporters
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Pharmacology and Therapeutics Discovery [PTD]
Education
BSc, Tel Aviv University
PhD, Columbia University
Postdoctoral Training, University of California, San Francisco
Language
English
Our lab focuses on the development and application of computational tools to annotate the functions of proteins. The two major research areas of our group include:
1. Structure-based drug design for membrane transporters. Our group characterizes cancer-related membrane transporter proteins, using a structure-based discovery approach, including homology modeling and virtual ligand screening, in collaboration with experimental labs. We rationally design novel chemical tools to study transporters’ role in cancer metabolism pathways, with a long-term goal of developing drugs against these potential cancer drug targets.
2. Structural bioinformatics. The lab works on developing and applying sequence-based and structure-based methods to predict different features of proteins using various machine-learning techniques. We analyze the predicted features of proteins in the context of networks and proteomes, to characterize protein functions.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Schlessinger during 2020 and/or 2021. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Company Founder:
- AIchemy, INC
Consulting:
- AIchemy, INC
- Apricity
- Parthenon Therapeutics
- ReSolute Consortium
- Trilogy Sciences INC
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- AIchemy, INC
Other activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
- AIchemy, INC
Scientific Advisory Board:
- AIchemy, INC
- Apricity
- ReSolute Consortium
- Trilogy Sciences INC
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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