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Achillefs Ntranos, MD Email Achillefs Ntranos

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Mount Sinai Doctors ?
    • Position
    • ASSISTANT PROFESSOR | Neurology, Multiple Sclerosis
    • Specialty
    • Neurology
    • Language
    • English
    • Hospital Affiliations
    • Mount Sinai Queens
    • Mount Sinai Morningside and Mount Sinai West
    • Mount Sinai Beth Israel
    • The Mount Sinai Hospital

Achillefs Ntranos, MD, is an Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai and the Corinne Goldsmith Dickinson Center for Multiple Sclerosis, specializing in multiple sclerorsis and demyelinating diseases. He sees patients at Mount Sinai Union Square.

Dr. Ntranos has conducted high-impact translational research in multiple sclerosis and neuroimmunology at Johns Hopkins and Mount Sinai, which he strives to integrate in his clinical practice to provide exceptional evidence-based patient care. His research has increased our understanding of how medications work in multiple sclerosis, which could help us personalize our treatment approach in the future. Apart from seeing patients, Dr. Ntranos is leading a translational research laboratory at Mount Sinai, where he continues to conduct innovative research on the cause of multiple sclerosis and how we can best stop inflammatory activity and progression of disease in each individual patient.

Dr. Ntranos received his medical degree from the National and Kapodistrian University of Athens Medical School in Greece, after which he joined Johns Hopkins University in Baltimore, Maryland, for his research fellowship in neuroimmunology. His work at Johns Hopkins revealed a new mechanism by which fingolimod was affecting the immune system and was awarded the Whitaker Prize for Multiple Sclerosis Research by the Foundation of the Consortium of Multiple Sclerosis Centers in 2013. During that time, he also contributed to the pilot trial of vitamin D supplementation in patients with multiple sclerosis to investigate its effect on the immune system, which was published in Neurology. After his internship in internal medicine at Albert Einstein School of Medicine, Dr. Ntranos joined the Icahn School of Medicine at Mount Sinai for his residency training in neurology, where he was nominated Chief Resident during his final year of the program. He then completed his fellowship in multiple sclerosis and demyelinating diseases at Mount Sinai, for which he received a research education grant from the National Institute of Neurological Diseases and Stroke and was awarded the Leon Levy Fellowship in Neurosciences.

Dr. Ntranos' work during his fellowship had a great impact on changing the view about how dimethyl-fumarate works in multiple sclerosis patients and highlighted that metabolites, such as dimethyl-fumarate, could modulate the immune system by altering the way the genetic code is being read via epigenetic mechanisms. This work was published on the cover and Editor's choice section of Brain, one of the top clinical neurology journals. While trying to translate his research findings to advance clinical practice, Dr. Ntranos proposed that the immunologic response to dimethyl-fumarate in the blood of individual patients could predict who is going to respond and who is not going to respond to the treatment in the future. These findings, which could help personalize our treatment approach in the future, were presented at two major scientific meetings, the American Academy of Neurology and the Americas Committee for Treatment and Research in Multiple Sclerosis in 2019.

Dr. Ntranos offers telemedicine appointments when appropriate. Please call his office to schedule a video visit.


Neurology, American Board of Psychiatry and Neurology

Clinical Focus

Research Topics

Epigenetics, Genomics, Immunology, Metabolomics, Multiple Sclerosis, Personalized Medicine, T Cells, Translational Research


MD, University of Athens Medical School

Internship, Internal Medicine
Albert Einstein School of Medicine

Residency, Neurology
Icahn School of Medicine at Mount Sinai

Fellowship, Multiple Sclerosis and Demyelinating diseases
Icahn School of Medicine at Mount Sinai