News Medical - "SUMO1 Protein May Treat and Prevent Heart Failure" - Dr. Roger Hajjar
A promising new drug target for the treatment and prevention of heart failure has been discovered by researchers at Mount Sinai School of Medicine.
The study was presented at the European Society of Cardiology (ESC) Congress 2012 by principal investigator Professor Roger J. Hajjar, MD. In this study researchers identified a new drug target that may treat and/or prevent heart failure. The team evaluated failing human and pig hearts and discovered that SUMO1 (small ubiquitin-like modifier), a small protein that regulates the activity of key transporter genes, was decreased in failing hearts. When the researchers injected SUMO1 into these hearts via gene therapy, cardiac function was significantly improved. "This indicates that SUMO1 may play a critical role in the pathogenesis of heart failure," said Professor Hajjar, who is research director of Mount Sinai's Wiener Family Cardiovascular Research Laboratories. Learn More