Ewing sarcoma
Bone cancer - Ewing sarcoma; Ewing family of tumors; Primitive neuroectodermal tumors (PNET); Bone neoplasm - Ewing sarcoma; Ewing's sarcoma
Ewing sarcoma is a malignant bone tumor that forms in the bone or soft tissue. It affects mostly teens and young adults.
X-rays are a form of ionizing radiation that can penetrate the body to form an image on film. Structures that are dense (such as bone) will appear white, air will be black, and other structures will be shades of gray depending on density. X-rays can provide information about obstructions, tumors, and other diseases, especially when coupled with the use of barium and air contrast within the bowel.
This X-ray shows a malignant bone tumor (Ewing sarcoma) of the upper arm bone (humerus). This type of tumor usually occurs during childhood and adolescence.
Causes
Ewing sarcoma can occur anytime during childhood and young adulthood. But it usually develops during puberty, when bones are growing rapidly. It is more common in White children than in Black or Asian children.
The tumor may start anywhere in the body. Most often, it starts in the long bones of the arms and legs, the pelvis, or the chest. It can also develop in the skull or the flat bones of the trunk.
The tumor often spreads (metastasizes) to the lungs and other bones. At the time of diagnosis, spread is seen in about one third of children with Ewing sarcoma.
In rare cases, Ewing sarcoma occurs in adults.
Symptoms
There are few symptoms. The most common is pain and sometimes swelling at the site of the tumor.
Children may also break a bone at the site of the tumor after a minor injury.
Fever may also be present.
Exams and Tests
If a tumor is suspected, tests to locate the primary tumor and any spread (metastasis) often include:
- Bone scan
- Chest x-ray
- CT scan of the chest
- MRI of the tumor
- X-ray of the tumor
A biopsy of the tumor will be done. Different tests are done on this tissue to help determine how aggressive the cancer is and what treatment may be best.
Treatment
Treatment often includes a combination of:
- Chemotherapy
- Radiation therapy
- Surgery to remove the primary tumor
Treatment depends on the following:
- Stage of the cancer
- Age and sex of the person
- Results of the tests on the biopsy sample
Support Groups
The stress of illness can be eased by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
Outlook (Prognosis)
Before treatment, outlook depends on:
- Whether the tumor has spread to distant parts of the body
- Where in the body the tumor started
- How large the tumor is when it's diagnosed
- Whether the LDH level in the blood is higher than normal
- Whether the tumor has certain gene changes
- Whether the child is younger than 15 years
- Child's sex
- Whether the child has had treatment for a different cancer before Ewing sarcoma
- Whether the tumor has just been diagnosed or has come back
The best chance for cure is with a combination of treatments that includes chemotherapy plus radiation or surgery.
Possible Complications
The treatments needed to fight this disease have many complications. Discuss these with your health care provider.
When to Contact a Medical Professional
Call your provider if your child has any of the symptoms of Ewing sarcoma. An early diagnosis can increase the possibility of a favorable outcome.
References
Heck RK, Toy PC. Malignant tumors of bone. In: Azar FM, Beaty JH, eds. Campbell's Operative Orthopaedics. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 27.
National Cancer Institute website. Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissue treatment (PDQ) - health professional version.
National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology (NCCN guidelines): Bone cancer. Version 2.2022.
Version Info
Last reviewed on: 1/25/2022
Reviewed by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
