Neurocognition After Perturbed Sleep
Study Phase: N/A
Recruitment Status: Recruiting
Start Date: September 01, 2021
End Date: May 01, 2023
Inclusion Criteria:
- Females or males age 18-60 years
- DSM-5 diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder
- Taking antipsychotic medication for >7 weeks and on current doses for 4 weeks, and/or injectable depot antipsychotics with no change in the last 3 months
- Capacity to understand all the potential risks and benefits of the study.
Exclusion Criteria:
- DSM-5 alcohol/substance diagnosis (except nicotine) within the last 6 months
- Taking medications affecting sleep propensity or architecture (other than antipsychotic medication)
- Initiation of medications known to impact cognition in previous 4 weeks or any change in doses during this period
- History of seizures/head trauma with loss of consciousness (>10 min) resulting in cognitive sequelae
- Medical or neurological conditions that could interfere with participation (e.g., untreated hypothyroidism
- Mental retardation
- Narcolepsy
- REM behavior disorder, parasomnias)
- Pregnant/ nursing
- Serious homicidal/suicidal risk (past 6 months)
- Moderate or more severe disorganization (PANSS≥4)
- Poor English reading ability (WTAR<7)
- Individuals employed as vehicle drivers/train operators or have occupations in which lapses in sustained vigilance would compromise safety
- Night shift workers or those with irregular sleep-wake rhythms (based on the week-long home actigraphy; i.e., average bedtime of 11pm±2 hours)
- Participation in the past 3 months in cognition study
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Conditions:
- Schizophrenia