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Full/Part Time: Full Time
Location/Affiliates: Mount Sinai Medical Center (Manhattan)
Department: 859 - Psychiatry
Requisition Number: PD13-1583556
A postdoctoral position is available in the laboratory of Dr. Joseph Buxbaum at Icahn School of Medicine at Mount Sinai, in New York City. The goal of our research is to understand the basic mechanisms underlying behavioral changes in autism. We have recently developed several genetically modified mouse and rat models of autism with interesting behavioral changes, and want to extend this work to detail the alterations in neuronal properties and circuitry that underlie these changes. We are looking for a highly motivated and independent candidate with strong background and publication record in neuroscience and expertise in vitro and in vivo electrophysiology. The lab is equipped for this type of science, and the Seaver Autism Center is a unique, integrated Center where clinicians, clinician-sciences and basic scientists work side-by-side in a translational setting (www.seaverautismcenter.org). The Departments of Psychiatry, Neuroscience, and Neurology are all in the top 20 best funded in the USA. Furthermore, the new Hess Center for Science and Medicine opened in 2012, increasing neuroscience research space by 30 percent.
*Responsibilities include designing and carrying out electrophysiological experiments in genetically modified mice and rats, using in vitro and in vivo recordings. Multiple brain regions will be analyzed, including prefrontal cortex, amygdala, hippocampus, striatum, etc, as well as connections between regions. Field and single cell recording, spontaneous and evoked release, and various measure of plasticity will be studied. Where appropriate to prove the involvement of a particular pathway in a given behavior, introduction of exogenous genes through viral injection, and the use of optogenetic methods will be required as well.
*The applicant will work closely with the behavioral data and with the biochemical data to provide an integrated view of the impact of mutation on molecular and cellular changes and ultimate behavioral changes.
*Responsibilities also include participation in all seminar and works in progress meetings, data management and analysis, and scientific writing.
*-indicates duty is "essential" as defined by the Americans with Disabilities Act (ADA)
Ph.D Neuroscience (electrophysiology) or related topic or discipline
2 years in research enviroment
Strong communication and writing skills.
Mount Sinai Medical Center is an equal opportunity/affirmative action employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds. Mount Sinai Medical Center--An EEO/AA-D/V Employer.