"Mar Matters" - Kelsey Kaustinen
A team from The Icahn School of Medicine at Mount Sinai working in the areas of schizophrenia, bipolar disorder and autism found that despite the benefits of stem cell-based disease modeling, there are some rare mutations that cannot be recreated in generated stem cells. “Our study describes how a complex chromosomal rearrangement genetically passed by a patient with psychosis to her affected son was not well recreated in laboratory-produced stem cells,” said researcher Kristen Brennand, PhD, an assistant professor of neuroscience at the Icahn School of Medicine at Mount Sinai. “We’re trying to show this is the rare example that this can happen, so that all stem cell scientists will try to be as careful in the future as we’re going to be going forward, knowing this is possible.
- Kristen Brennand, PhD, Assistant Professor, Psychiatry, Neuroscience, Icahn School of Medicine at Mount Sinai