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Thomas Bryce

  • ASSOCIATE PROFESSOR Rehabilitation Medicine
  • ASSOCIATE PROFESSOR Neurosurgery
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Certifications

  • Physical Medicine & Rehabilitation - Pain Management

  • Physical Medicine & Rehabilitation

Clinical Focus

Education

  • MD, Albany Medical College

  • Internship, Internal Medicine
    Albany Medical Center

  • Residency, Rehabilitation Medicine
    Thomas Jefferson University Hospital

Biography

    Dr. Thomas Bryce came to The Mount Sinai Medical Center in 1997 and has served as Medical Director of the Spinal Cord Injury Program since 2001 and as Medical Director of Rehabilitation Ambulatory Services since 2008. He is an Associate Professor of Rehabilitation Medicine and Neurosurgery at the Icahn School of Medicine at Mount Sinai.

    He received his undergraduate degree from Johns Hopkins University and his medical degree from Albany Medical College. He received specialty training in Rehabilitation Medicine at Thomas Jefferson University Hospital.

    Dr. Bryce is board certified in Physical Medicine and Rehabilitation and has sub-specialty certification in both Pain Medicine and Spinal Cord Injury Medicine.

    Dr. Bryce is involved with research related to spinal cord injury especially as it relates to the assessment of pain after spinal injury, use of robotic exoskeletons to facilitate walking, and stem cell implantation for neurological recovery after spinal cord injury. He is the principle investigator of several ongoing studies in these areas. He has authored numerous chapters and scientific articles on spinal cord injury.

    Dr. Bryce has been appointed by Governor Cuomo to the New York State Spinal Cord Research Board.

    Dr. Bryce is on the steering committee of the Consortium for Spinal Cord Medicine, a consortium of national organizations which publishes clinical guidelines related to the care of individuals with spinal cord injury. He has been a research grant reviewer for the Department of Defense, the European Science Foundation, and the Craig H. Neilsen Foundation.

    Dr. Bryce works closely with physical therapists, occupational therapists, neuropsychologists, and other medical and surgical specialists in order to provide comprehensive care.

    Dr. Bryce performs all aspects of spasticity management especially as related to intrathecal therapy screening and management from intrathecal test trials to refills and dose adjustments.

Research

Dr. Bryce has been involved in several international taskforces related to outcome measures for pain after spinal cord injury, the International Dataset Project, and the classification of pain after spinal cord injury. The last of which he chaired.

At Mount Sinai, Dr. Bryce has been either the principal investigator or site principal investigator for the following funded studies:

A multi-center phase 2 trial eval-uating the efficacy and safety of our neural stem cells (HuCNS-SC) in patients with chronic cervical spinal cord injury

Evoked neuropathic pain in spinal cord injury

A phase II, multiple dose, double blinded, placebo controlled  study of HP184 in chronic spinal cord injury patients

A multiple dose, double blinded, placebo controlled safety, tolerability and pharmacokinetic/ pharmacodynamic study of HP184 in chronic spinal cord injury patients

A multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the safety and efficacy of repeat treatment with two dose levels of BOTOX (r) (Botulinum Toxin Type A) purified neurotoxin complex followed by a treatment with BOTOX(r) in patients with urinary incontinence due to neurogenic detrusor overactivity

Publications

Bryce TN, Richards JS, Bombardier CH, Dijkers MP, Fann JR, Brooks L, Chiodo A, Tate DG, Forchheimer M. Screening for neuropathic pain after spinal cord injury with the spinal cord injury pain instrument (SCIPI): a preliminary validation study. Spinal cord 2014 May; 52(5).

Bryce TN, Biering-Sørensen F, Finnerup NB, Cardenas DD, Defrin R, Lundeberg T, Norrbrink C, Richards JS, Siddall P, Stripling T, Treede RD, Waxman SG, Widerström-Noga E, Yezierski RP, Dijkers M. International spinal cord injury pain classification: part I. Background and description. March 6-7, 2009. Spinal cord 2012 Jun; 50(6).

Bryce TN, Biering-Sørensen F, Finnerup NB, Cardenas DD, Defrin R, Ivan E, Lundeberg T, Norrbrink C, Richards JS, Siddall P, Stripling T, Treede RD, Waxman SG, Widerström-Noga E, Yezierski RP, Dijkers M. International Spinal Cord Injury Pain (ISCIP) Classification: Part 2. Initial validation using vignettes. Spinal cord 2012 Jun; 50(6).

Bryce TN, Budh CN, Cardenas DD, Dijkers M, Felix ER, Finnerup NB, Kennedy P, Lundeberg T, Richards JS, Rintala DH, Siddall P, Widerstrom-Noga E. Pain after spinal cord injury: an evidence-based review for clinical practice and research. Report of the National Institute on Disability and Rehabilitation Research Spinal Cord Injury Measures meeting. The journal of spinal cord medicine 2007; 30(5).

Widerström-Noga E, Biering-Sørensen F, Bryce TN, Cardenas DD, Finnerup NB, Jensen MP, Richards JS, Siddall PJ. The International Spinal Cord Injury Pain Basic Data Set (version 2.0). Spinal cord 2014 Apr; 52(4).

Cardenas D, Bryce T, Shem K, Richards J, Elhefni H. Gender and minority differences in the pain experience of people with spinal cord injury. Arch Phys Med Rehabil 2004; 85: 1174-1181.

Bryce T, Dijkers M, Ragnarsson K, Stein A, Chen B. Reliability of the Bryce-Ragnarsson SCI pain taxonomy. J Spinal Cord Med 2006; 29: 118-132.

Bryce T, Dijkers M, Apple D. Sipski M, editor. Assessment of pain after SCI in clinical trials. 2006.prettyprintp50-68.

Bryce T, Norrbrink Budh C, Cardenas D, Dijkers M, Felix E, Finnerup N, Kennedy P, Lundeberg T, Richards J, Rintala D, Siddall P, Widerstorm-Noga E. Pain after Spinal Cord Injury: An Evidenced-based Review for Clinical Practice and Research. Report of the National Institute on Disability and Rehabilitation Research Spinal Cord Injury Measures Meeting- Pain Committee. J Spinal Cord Med 2007; 30: 421-440.

Bryce T, Apple D, Richards J. and classification of pain after spinal cord injury. In: Ragnarsson K, editor. Topics in Spinal Cord Injury Rehabilitation.prettyprintp1-17.

Bryce T, Sheth P, Chen B, Ragnarsson K. Spinal Orthoses. In: Slipman C, Derby R, Simeonw F, Mayer T, editors. Interventional spine: an algorithmic approach. philidelphia, Saunders Elsevier;.

Bryce T, Ragnarsson K. Pain after spinal cord injury. In: Kraft G, Hammond M, editors. Topics in Spinal Cord Injury Medicine. Physical Medicine and Rehabilitation Clinics of North America;prettyprintp157-168.

Bryce T, Ragnarsson K, Stein A. Spinal Cord Injury. In: Braddom R, editor. Physical Medicine and Rehabilitation, 3rd Edition. Philadelphia, Saunders Elsevier;.

Bryce T, Ragnarsson K. Pain management in persons with spinal cord disorders. In: Lin V, editor. Spinal Cord Medicine: principles and practice. New York, Demos;.

Bryce T, Ragnarsson K. Rehabilitation after spinal cord injury. In: Devlin V, editor. Spine Secrets. philidelphia, hanley and belfus;.

Margolis JM, Juneau P, Sadosky A, Cappelleri JC, Bryce TN, Nieshoff EC. Health care utilization and expenditures among Medicaid beneficiaries with neuropathic pain following spinal cord injury. Journal of pain research 2014; 7.

Margolis JM, Juneau P, Sadosky A, Cappelleri JC, Bryce TN, Nieshoff EC. Health Care Resource Utilization and Medical Costs of Spinal Cord Injury With Neuropathic Pain in a Commercially Insured Population in the United States. Archives of physical medicine and rehabilitation 2014 Aug;.

Alexander MS, Anderson KD, Biering-Sorensen F, Blight AR, Brannon R, Bryce TN, Creasey G, Catz A, Curt A, Donovan W, Ditunno J, Ellaway P, Finnerup NB, Graves DE, Haynes BA, Heinemann AW, Jackson AB, Johnston MV, Kalpakjian CZ, Kleitman N, Krassioukov A, Krogh K, Lammertse D, Magasi S, Mulcahey MJ, Schurch B, Sherwood A, Steeves JD, Stiens S, Tulsky DS, van Hedel HJ, Whiteneck G. Outcome measures in spinal cord injury: recent assessments and recommendations for future directions. Spinal cord 2009 Aug; 47(8).

Forchheimer MB, Richards JS, Chiodo AE, Bryce TN, Dyson-Hudson TA. Cut point determination in the measurement of pain and its relationship to psychosocial and functional measures after traumatic spinal cord injury: a retrospective model spinal cord injury system analysis. Archives of physical medicine and rehabilitation 2011 Mar; 92(3).

Dijkers MP, Bryce TN. Introducing the International Spinal Cord Injury Pain (ISCIP) Classification. Pain management 2012 Jul; 2(4).

Bryce TN, Ivan E, Dijkers M. Proposed International Spinal Cord Injury Pain (ISCIP) Classification:: Preliminary Validation Data. Topics in spinal cord injury rehabilitation 2012; 18(2).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Bryce did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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