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Terry Davies

  • PROFESSOR Medicine, Endocrinology, Diabetes and Bone Disease
  • PROFESSOR Obstetrics, Gynecology and Reproductive Science
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Education

  • MD, University of Newcastle-Upon-Tyne

  • National Institute of Health

  • M.D., University of New Castle-Upon-Tyne

  • Residency, Internal Medicine
    University of Newcastle-Upon-Tyne

  • Residency, Endocrinology & Metabolism
    University of Newcastle-Upon-Tyne

  • Fellowship, Endocrinology & Metabolism
    National Institutes of Health

Biography

    Terry Francis Davies is the Florence and Theodore Baumritter Professor of Medicine at the Mount Sinai School of Medicine in New York and Director of their Division of Endocrinology and Metabolism at the James J. Peters VA Medical Center. Dr. Davies was trained in the UK, at the University of Newcastle upon Tyne but after training at the National Institutes of Health in Bethesda, MD, has spent most of his career in New York at the Mount Sinai School of Medicine. He has a long and distinguished record of significant contributions to our understanding of endocrine physiology and pathology having published over 400 peer reviewed scientific papers mostly in the area of thyroid disease at both a basic level, in the areas of immunology and genetics, and in the clinical arena in the area of autoimmune thyroid disease and pregnancy. Although Dr. Davies, as a clinician, is always included in the lists of New York's Best Doctors, the Davies Laboratory remains one of our pre-eminent sites for autoimmune thyroid disease research as evidenced by his extensive support from the National Institutes of Health.  Dr. Davies has received many honors in his career, is a member of the American Association of Physicians and is the President-Elect of the American Thyroid Association.  Dr. Davies was recently chosen by Women's Health as the pre-eminent Endocrinologist for women in New York City.

Awards

  • 2009 -
    Best Doctors
    New York Magazine

  • 2008 -
    Invited lecture
    International Autoimmunity Conference, Porto, Portugal

  • 2008 -
    President Elect
    American Thyroid Association

  • 2007 -
    Honorary President for Life
    United States Friends of Newcastle University

  • 2006 -
    Veterans Affairs Merit Award

  • 2006 -
    Plenary Lecture
    Canadian Society for Endocrinology, Toronto

  • 2006 -
    Invited Lecture
    International Autoimmunity Congress, Sorrento, Italy

  • 2005 -
    Plenary Lecture
    German Endocrine Society, Muenster

  • 2004 -
    Plenary Lecture
    4th International Congress on Autoimmunity, Budapest, Hungary

  • 2003 -
    Plenary Lecture
    Australian Endocrine Society, Melbourne

  • 2002 -
    Higgins Award
    Thyroid Foundation of America

Research

Specific Clinical/Research Interest:
Mechanisms in autoimmune disease with an emphasis on autoimmune thyroid disease

Postdoctoral Fellows: Marco Agote-Robertson PhD, Sayed Moshad PhD, Chris Michalek MD, PhD, Risheng Ma, PhD

Research Personnel: Rauf Latif PhD, Xiaoming Yin PhD, Zhong Yao

Summary of Research Studies:
Research areas of emphasis include: The TSH receptor molecule: This is the major autoantigen in human Graves' disease which is a form of autoimmune hyperthyroidism. The TSHR remains an elusive quarry ten years after it was cloned becsue of its highly complex processing. Our emphasis is on the post translational processing events involved with multimerization and intramolecular cleavage of the TSHR and its status in lipid rafts. Complex Genetics: The aim of this research has been to detect the susceptibility genes for autoimmune thyroid disease using genome screening of informative families with Graves' disease and/or Hashimoto's thyroiditis. Our group has experience in the analysis of families with these disorders and we have a large collection of well characterized families to study. Currently, our areas of emphasis are on individual susceptibility genes. In particular the TSH receptor intron 1 region where we have identified miRNAs close to associated SNPs and the role of epigenetics(using X chromosome inactivation) in disease susceptibility and its influence on the autoimmune response. Animal models of autoimmune thyroid disease: We have developed models of hyperthyroid mice immunized with an adenoviral vector incorporating the TSH receptor as a model for Graves' disease. These studies involve the development and characterization of unique monoclonal antibodies to the TSH receptor with thyroid stimulating activity with an emphasis on epitope characterization and signal transduction.

Publications

Lu A, Ng L, Ma M, Kefas B, Davies TF, Hernandez A, Chan CC, Forrest D. Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice. Endocrinology 2008 Oct 30; Epub ahead of print.

Yin X, Latif R, Bahn R, Tomer Y, Davies TF. Influence of the TSH Receptor Gene on Susceptibility to Graves' Disease and Graves' Ophthalmopathy. Thyroid 2008 Oct 16;.

Menconi F, Monti MC, Greenberg DA, Oashi T, Osman R, Davies TF, Ban Y, Jacobson EM, Concepcion ES, Li CW, Tomer Y. Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proc Natl Acad Sci U S A 2008 Sep 16; 105(37): 105-109.

Characterization of TSH receptor antibody induced signaling cascades [Epub ahead of print]. Endocrinology 2008 Aug 21;.

Ban Y, Greenberg DA, Davies TF, Jacobson E, Concepcion E, Tomer Y. Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease. J Clin Endocrinol Metab 2008 Sep; 93(9): 3589-3596.

Vieland VJ, Huang Y, Bartlett C, Davies TF, Tomer Y. A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications. Am J Hum Genet 2008 Jun; 82(6): 1349-1356.

Sun L, Vukicevic S, Baliram R, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah K, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M. Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A 2008 Mar 18; 105(11): 4289-4294.

Galofre JC, Lomvardis S, Davies TF. Evaluation and treatment of thyroid nodules: A clinical guide. Mount Sinai Journal of Medicine 2008; 75: 299-311.

Tomer Y, Menconi M, Davies TF, Barbesubi G, Rocchi R, Pinchera A, Concepcio E, Greenberg DA. Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis. Journal of Autoimmunity 2007; 29: 69-77.

Ando T, Latif R, Abe E, Davies TF. Antibody-induced modulation of TSH receptor post-translational processing. Journal of Endocrinology 2007; 195: 179-186.

Latif R, Davies TF. Lipid rafts as triage centers for multimeric and monomeric TSH receptor regulation. Endocrinology 2007; 148: 3164-3175.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Davies during 2013 and/or 2014. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

  • KRONUS

Scientific Advisory Board:

  • KRONUS

Service on Board of Directors: Service in a fiduciary capacity, such as an officer or director, for the following companies:

  • KRONUS

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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