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Stephen Salton

  • PROFESSOR Neuroscience
  • PROFESSOR Geriatrics and Palliative Medicine
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Training Areas

Education

  • Internship and Residency, Bellevue and NYU School of Medicine
    Internal Medicine

  • Ph.D., New York University

  • Fellowship, Columbia Presbyterian and Mount Sinai School of Medicine
    Neuroscience

  • M.D., New York University

  • B.A., University of Pennsylvania

Biography

Awards

  • 2008 - 2010
    NARSAD van Ameringen Investigator

  • 2006 - 2008
    NARSAD Independent Investigator

  • 1994 - 1999
    Irma T. Hirschl Career Scientist

  • 1991 - 1995
    Pew Scholar in the Biomedical Sciences

  • 1989 - 1991
    Pfizer Scholar

  • 1986 - 1988
    Pfizer Postdoctoral Fellow

Research

Research

Specific Clinical/Research Interests:  Molecular Neuroscience; Neurotrophin Signaling; Neuropeptides; Neural Cell Adhesion Molecules; Obesity; Diabetes; Depression.

Current Students: PhD: Cheng Jiang (Neuroscience), MS: Masato Sadahiro, Amy Frick

Postdoctoral Fellows: Samira Fargali, Wei-Jye Lin, Jelle Welagen

Research Personnel: Valeria Cogliani

Summary of Research Studies: Our research is focused on understanding the mechanisms by which neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development and function.  BDNF and NGF have been implicated in the pathophysiology of neurodegenerative disease, neuropsychiatric illness, CNS injury, and obesity. The contributions made by specific neurotrophin-regulated gene products to depression, memory, and energy balance, are being being examined using novel knockout, transgenic, and knockin mouse models.  The lab has identified VGF, a secreted peptide precursor and granin family member, and the cell adhesion molecule (CAM) L1 or NILE, as important gene products that are induced by neurotrophin exposure during neural differentiation. Cultured neurons, neural and endocrine cell lines, and hippocampal slices are all utilized to study effects of these proteins on synaptic plasticity, neurogenesis, axonal outgrowth, and axonal pathfinding.  Conservation of function of neurotrophin-regulated proteins, including VGF and L1, in simpler vertebrate models such as zebrafish, is also under investigation.  We are currently determining the potential functional roles and signaling pathways of these and other neurotrophin-regulated molecules in clinically relevant diseases, including major depression, neuropathic pain, obesity, and fetal alcohol syndrome.

Visit Dr. Stephen Salton's Lab for more information.

Publications

Fairbanks CA, Peterson CD, Speltz RH, Riedl MS, Kitto KF, Dykstra JA, Braun PD, Sadahiro M, Salton SR, Vulchanova L. The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity. Pain 2014 Mar;.

Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J 2014 Feb;.

Fargali S, Scherer T, Shin AC, Sadahiro M, Buettner C, Salton SR. Germline ablation of VGF increases lipolysis in white adipose tissue. J Endocrinol 2012 Nov; 215(2).

Bartolomucci A, Possenti R, Mahata SK, Fischer-Colbrie R, Loh YP, Salton SR. The extended granin family: structure, function, and biomedical implications. Endocr Rev 2011 Dec; 32(6).

Carcea I, Ma'ayan A, Mesias R, Sepulveda B, Salton SR, Benson DL. Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A. J Neurosci 2010 Nov; 30(45).

Watson E, Fargali S, Okamoto H, Sadahiro M, Gordon RE, Chakraborty T, Sleeman MW, Salton SR. Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure. BMC Physiol 2009; 9.

Moss A, Theodorou A, Low L, Ingram R, Kock S, Baccei M, Hathway GJ, Costigan M, Salton SR, Fitgerald M. Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurons following peripheral nerve injury. Mol Pain 2008 Dec; 4(1): 62.

Bozdagi O, Rich E, Tronel S, Sadahiro M, Patterson K, Shapiro ML, Alberini C, Huntley GW, Salton SR. The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a BDNF-dependent mechanism. J Neurosci 2008; 28: 9857-9869.

Mintz CD, Carcea I, Burke ME, McNickle DG, Ge YC, Dickson TC, Salton SR, Benson DL. ERM proteins regulate response and adaptation to Sema3A. J Comp Neurol 2008; 510: 351-366.

Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS. Novel antidepressant actions of the exercise-regulated gene VGF. Nat Med 2007 Dec; 13(12): 1476-1482.

Watson E, Hahm S, Mizuno TM, Windsor J, Montgomery C, Scherer PE, Mobbs CV, Salton S. VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 2005 Dec; 146(12): 5151-63.

Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem 2005 Dec 16; 280(50): 41595-608.

Hahm S, Fekete C, Mizuno TM, Windsor J, Yan H, Boozer CN, Lee C, Elmquist JK, Lechan RM, Mobbs CV, Salton SV. VGF is required for obesity induced by diet, gold thioglucose treatment and agouti, and is differentially regulated in POMC- and NPY-containing arcuate neurons in response to fasting. J Neurosci 2002; 22: 6929-6938.

Dickson TC, Mintz CD, Benson DL, Salton SR. Functional binding interaction identified between the axonal CAM L1 and members of the ERM family. J Cell Biol 2002 Jun 24; 157(7): 1105-12.

Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, Mc Evoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR. Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron 1999 Jul; 23(3): 537-48.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Salton did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Tel: 212-659-5901
Fax: 212-996-9785