Dr. Iyengar is a Dorothy H. and Lewis Rosenstiel Professor in the Department of Pharmacology and Systems Therapeutics and the Director and Principal Investigator of the NIGMS funded Systems Biology Center New York.
Trained as a biochemist, Dr. Iyengar's research focuses on cell signaling networks with emphasis on heterotrimeric G protein pathways. His laboratory uses a combination of experimental and computational approaches to understand the regulatory and information processing capabilities of cellular signaling networks.
Systems pharmacology and systems biology
Computational cell biology
Cellular signaling networks
Spatial modeling of cell signaling
G-protein mediated intracellular signaling in neurons
Spatiotemporal organization of cellular networks
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BS, Bombay University
MSc, Bombay University
MS, University of Houston
PhD, University of Houston
Fellowship, Baylor College of Medicine
Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
Azeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R. Interconnected network motifs control podocyte morphology and kidney function. Science Signaling 2014; 7(311).
Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems Pharmacology of Adverse Event Mitigation by Drug Combinations. Science Translational Medicine 2013 Oct; 5(206).
Rangamani P, Lipshtat A, Azeloglu EU, Calizo RC, Hu M, Ghassemi S, Hone J, Scarlata S, Neves SR, Iyengar R. Decoding information in cell shape. Cell 2013 Sep; 154(6).
Iyengar R, Zhao S, Chung SW, Mager DE, Gallo JM. Merging systems biology with pharmacodynamics. Science Translational Medicine 2012 Mar; 4(126).
Rangamani P, Fardin MA, Xiong Y, Lipshtat A, Rossier O, Sheetz MP, Iyengar R. Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading. Biophysical Journal 2011 Feb; 100(4): 845-857.
Xiong Y, Rangamani P, Fardin MA, Lipshtat A, Dubin-Thaler B, Rossier O, Sheetz MP, Iyengar R. Mechanisms controlling cell size and shape during isotropic cell spreading. Biophysical Journal 2010 May; 98(10): 2136-2146.
Berger SI, Ma'Ayan A, Iyengar R. Systems pharmacology of arrhythmias. Science Signaling 2010 Apr; 3(118): ra30.
Lipshtat A, Jayaraman G, He JC, Iyengar R. Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues. Proc Natl Acad Sci U S A 2010 Jan; 107(3): 1247-1252.
Ma'ayan A, Cecchi GA, Wagner J, Rao AR, Iyengar R, Stolovitzky G. Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks. Proc Natl Acad Sci U S A 2008 Dec; 105(49): 19235-19240.
Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell 2008 May; 133(4): 666-680.
Bromberg KD, Ma'ayan A, Neves SR, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science 2008 May; 320(5878): 903-909.
Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science 2005 Aug; 309(5737): 1078-1083.
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Dr.Iyengar did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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