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Sophia Frangou

  • PROFESSOR Psychiatry
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    Dr. Frangou serves as Professor of Psychiatry and Chief of the Psychosis Research Program in the Division of Psychiatric Genomics in the Department of Psychiatry.

    A leading authority on neuroimaging in schizophrenia and bipolar disorder, Dr. Frangou was recruited to Mount Sinai to establish a Clinical and Translational Psychosis Program. By building on Mount Sinai’s strengths in clinical investigation, the program aims to transfer research in genetics, neuroimaging, and neurobiology into clinical trials and clinical care.

    Dr. Frangou has published highly innovative research on the use of neuroimaging as a diagnostic and evaluation tool for psychosis. Her work has marked out the neural pathways associated with disease expression, vulnerability, and resilience and their association with known genetic risk factors. This body of work represents important paradigm shifts in refining conceptual models for psychosis and has the potential to reduce public skepticism of psychiatry and the stigmatization of patients.

    Prior to joining Mount Sinai, Dr. Frangou was Professor of Psychiatry and Head of the Section of Neurobiology of Psychosis at King’s College London. During her tenure, Dr. Frangou led two research programs at the Institute of Psychiatry in London—Vulnerability Indicators for Psychosis and Vulnerability Indicators for Bipolar Disorders—that examined biological markers associated with the diagnosis and genetic risk within and between mood disorders and psychosis. She also served as Consultant Psychiatrist at South London and Maudsley NHS Foundation Trust where she oversaw an 18-bed inpatient unit for patients with recurrent mood and psychotic disorders.

    Dr. Frangou had a significant mentoring role in her previous post as Training Program Director for trainees on a dual doctorate and clinical certification tract, which established the national and international reputation of the Institute of Psychiatry in training. In her new position, Dr. Frangou will help train the next generation of translational neuroscientists and clinicians in psychosis.

    Clinical Interests:

    Affective and Non-affective Psychosis
    Bipolar Disorder
    Brain Connectivity
    Genetic Imaging
    Multimodal data analyses
    Biological predictors of diagnosis and treatment response


Rocha-Rego V, Jogia J, Marquant A, Mourao-Mirand J, Simmons A, Frangou S. . Examination of the Predictive Value of Structural MR Scans in Bipolar Disorder: A Pattern Classification Approach. Psychol Med 2013;.

Reinares M, Papachristou E, Harvey P, Mar Bonnín C, Sánchez-Moreno J, Torrent C, Ayuso-Mateos JL, Ploubidis GB, Vieta E, Frangou S. Towards a clinical staging for bipolar disorder: defining patient subtypes based on functional outcome. Journal of affective disorders 2013 Jan; 144(1-2).

Sugranyes G, Kyriakopoulos M, Dima D, O'Muircheartaigh J, Corrigall R, Pendelbury G, Hayes D, Calhoun VD, Frangou S. Multimodal analyses identify linked functional and white matter abnormalities within the working memory network in schizophrenia. Schizophrenia research 2012 Jul; 138(2-3).

Dima D, Stephan KE, Roiser JP, Friston KJ, Frangou S. Effective connectivity during processing of facial affect: evidence for multiple parallel pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct; 31(40).

Kempton MJ, Salvador Z, Munafò MR, Geddes JR, Simmons A, Frangou S, Williams SC. Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder. Archives of general psychiatry 2011 Jul; 68(7).

Pompei F, Dima D, Rubia K, Kumari V, Frangou S. Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder. NeuroImage 2011 Jul; 57(2).

Jogia J, Ruberto G, Lelli-Chiesa G, Vassos E, Maierú M, Tatarelli R, Girardi P, Collier D, Frangou S. The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder. Molecular psychiatry 2011 Nov; 16(11).

Kempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, Frangou S. Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals. The American journal of psychiatry 2009 Dec; 166(12).

Kempton MJ, Haldane M, Jogia J, Grasby PM, Collier D, Frangou S. Dissociable brain structural changes associated with predisposition, resilience, and disease expression in bipolar disorder. The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Sep; 29(35).

Tomelleri L, Jogia J, Perlini C, Bellani M, Ferro A, Rambaldelli G, Tansella M, Frangou S, Brambilla P. Brain structural changes associated with chronicity and antipsychotic treatment in schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2009 Dec; 19(12).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Frangou during 2014 and/or 2015. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Scientific Advisory Board:

  • Enzymotec, Ltd.; Janssen-Cilag (Johnson & Johnson)

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at Patients may wish to ask their physician about the activities they perform for companies.

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