Sergio Lira, MD, PhD Email Sergio Lira
- PROFESSOR | Medicine, Clinical Immunology
Brain, Cancer, Cell Motility, Cellular Immunity, Chemokines, Chemotaxis, Imaging, Immunology, Inflammation, Knockout Mice, Macrophage, Microglia, Oncogenes, Organogenesis, Pathology, T Cells, Transgenic Mice, Tumorigenesis, Viruses and Virology
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Immunology [IMM]
, Roche Institute of Molecular Biology
MD, U. Federal de Pernambuco
PhD, University of California
Specific Clinical/Research Interest: Chemokines; leukocyte trafficking; angiogenesis; lymphoid development; mouse genetics; cancer inflammation
Postdoctoral Fellows: Lili Chen, Zhengziang He, Vladislav Volarevic
Research Personnel: Research Assistants: Claudia Canasto, Madhura Deshpande, Miranda Mao, Joshua Rivera
Summary of Research Studies:
We use genetic approaches in mice to study the function of cytokines and their receptors in leukocyte trafficking, inflammation and cancer. Recent work in the laboratory focuses:
1) on the role of chemokine-like molecules encoded by herpes and poxviruses in immune evasion and tumorigenesis; and
2) on the role of chemokines in lymphoid organogenesis and autoimmunity.
3) role of microbiome inflammation in cancer.
For more information, please visit the Immunology Institute website.
Lu G, Zhang R, Geng S, Peng L, Jayaraman P, Chen C, Xu F, Yang J, Li Q, Zheng H, Shen K, Wang J, Liu X, Wang W, Zheng Z, Qi CF, Si C, He JC, Liu K, Lira SA, Sikora AG, Li L, Xiong H. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nature communications 2015; 6.
Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA. CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN. Journal of the American Society of Nephrology : JASN 2015 Mar;.
Berres ML, Lim KP, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrão M, Lira SA, Heym KM, Clausen BE, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. The Journal of experimental medicine 2015 Feb; 212(2).
Chen L, He Z, Slinger E, Bongers G, Lapenda TL, Pacer ME, Jiao J, Beltrao MF, Soto AJ, Harpaz N, Gordon RE, Ochando JC, Oukka M, Iuga AC, Chensue SW, Blander JM, Furtado GC, Lira SA. IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology. Mucosal immunology 2015 Mar; 8(2).
Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U. CXCL5 drives neutrophil recruitment in TH17-mediated GN. Journal of the American Society of Nephrology : JASN 2015 Jan; 26(1).
Noriega VM, Gardner TJ, Redmann V, Bongers G, Lira SA, Tortorella D. Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination. Viruses 2014; 6(3).
Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, Furtado GC, Ochando J, Kelley KA, Clemente JC, Merad M, van Bakel H, Lira SA. Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice. The Journal of experimental medicine 2014 Mar; 211(3).
Furtado GC, Pacer ME, Bongers G, Bénézech C, He Z, Chen L, Berin MC, Kollias G, Caamaño JH, Lira SA. TNFα-dependent development of lymphoid tissue in the absence of RORγt⁺ lymphoid tissue inducer cells. Mucosal immunology 2014 May; 7(3).
Hammerich L, Bangen JM, Govaere O, Zimmermann HW, Gassler N, Huss S, Liedtke C, Prinz I, Lira SA, Luedde T, Roskams T, Trautwein C, Heymann F, Tacke F. Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology (Baltimore, Md.) 2014 Feb; 59(2).
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Dr. Lira has not yet completed reporting of Industry relationships.
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