- DIRECTOR IMMUNOLOGY INSTITUTE
- PROFESSOR Medicine, Clinical Immunology
- Cell Motility
- Cellular Immunity
- Endothelial Cells
- Knockout Mice
- Multiple Sclerosis
- Stem Cells
- T Cells
- Transgenic Mice
- Vascular Development
- Viruses and Virology
Roche Institute of Molecular Biology
M.D., U. Federal de Pernambuco
Ph.D., University of California
- Co-Director, Immunology Institute, Mount Sinai School of Medicine
Specific Clinical/Research Interest: Chemokines; leukocyte trafficking; angiogenesis; lymphoid development; mouse genetics
Current Students: Luciana Muniz
Postdoctoral Fellows: Gerold Bongers, Erik Slinger
Research Personnel: Research Assistant: Michelle Pacer
Summary of Research Studies:
We use genetic approaches in mice to study the function of chemokines and their receptors in leukocyte trafficking, angiogenesis, inflammation and cancer. Recent work in the laboratory focuses:
1) on the role of chemokine-like molecules encoded by herpes and poxviruses in immune evasion and tumorigenesis; and
2) on the role of chemokines in lymphoid organogenesis and autoimmunity.
For more information, please visit the Immunology Institute website.
Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5(+) T(H)2 cells. Nat Immunol. 2011 Feb;12(2):167-77.
Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, Tortorella D, Smit MJ, Lira SA. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. J Clin Invest. 2010 Nov 1;120(11):3969-78.
Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS .Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010 Aug 12;466(7308):829-34.
Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, Fraile-Ramos A, Lira SA, Söderberg-Nauclér C, Smit MJ. HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Sci Signal. 2010 Aug 3;3(133):ra58.
Viejo-Borbolla A, Martin AP, Muniz LR, Shang L, Marchesi F, Thirunarayanan N, Harpaz N, Garcia RA, Apostolaki M, Furtado GC, Mayer L, Kollias G, Alcami A, Lira SA. Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD. Mucosal Immunol. 2010 Nov;3(6):633-44.
Alcami A, Lira SA. Modulation of chemokine activity by viruses. Curr Opin Immunol. 2010 Aug;22(4):482-7.
Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, Price J, Yin N, Bromberg J, Lira SA, Stanley ER, Nussenzweig M, Merad M. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med. 2009 Dec 21;206(13):3115-30.
Marchesi F, Martin AP, Thirunarayanan N, Devany E, Mayer L, Grisotto MG, Furtado GC,Lira SA. CXCL13 expression in the gut promotes accumulation of IL-22-producing lymphoid tissue-inducer cells, and formation of isolated lymphoid follicles. Mucosal Immunol. 2009 Nov;2(6):486-94.
Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, Stanley ER, Nussenzweig M, Lira SA, Randolph GJ, Merad M. Origin of the lamina propria dendritic cell network. Immunity. 2009 Sep 18;31(3):513-25.
Martin AP, Marinkovic T, Canasto-Chibuque C, Latif R, Unkeless JC, Davies TF, Takahama Y, Furtado GC, Lira SA .CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism. J Immunol. 2009 Sep 1;183(5):3073-80.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Lira during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Scientific Advisory Board:
- Dompe Farmaceutici S.p.A.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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