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Scott Brodie

  • PROFESSOR Ophthalmology
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Certifications

  • Ophthalmology

Clinical Focus

Education

  • MD, Cornell University Medical College

  • Residency, Internal Medicine
    New York Hospital

  • Residency, Ophthalmology
    New York Hospital - Cornell Medical Center

  • Fellowship, Ophthalmology/Retina
    New York University Medical Center

Biography

    Dr. Scott Brodie is a Professor of Ophthalmology specializing in Medical Retina and Clinical Electrophysiology, and since 1985 has been the Director of the Department's Clinical Electrophysiology Laboratory. With expansive backgrounds in mathematics, biophysics, and genetics, he brings a unique perspective to the study of inherited, metabolic, and degenerative diseases of the retina in his clinical practice and research. He has developed and directs a comprehensive state-of-the-art clinical and research electrophysiologic laboratory, which provides the co mplete range of physiologic testing of visual fuction, including

           ·         Full-field (“Ganzfeld) Electroretinography (ERG)

           ·         Patern ERG

    ·         Multifocal ERG

    ·         Visual Evoked Potentials (VEP)

    ·         Electro-oculography

    ·         Color-vision testing (including Ishihara, HRR, Farnsworth D-15, Desaturated 15 Hue, F-M 100 Hue, and Nagel Anomaloscope)

    ·         Dark Adaptometry

     

    The full spectrum of standard clinical tests, including contrast sensitivity, Humphrey and Goldmann visual fields, fundus photography, spectral-mode optical coherence tomography (OCT), and fundus autofluorescence imaging are also available.

    Dr. Brodie received his B.A. Summa Cum Laude and an M.A. in Mathematics from Wesleyan University. He received his Ph.D. in biophysics from The Rockefeller University and his M.D. from Cornell University Medical College. After his residency at The New York Hospital, he received his fellowship in medical retina at New York University Medical Center where he held the John Kluge Fellowship from the National Retinitis Pigmentosa Foundation. Dr. Brodie is a Diplomate of the American Board of Ophthalmology.

    Dr. Brodie has published over 75 medical and scientific, primarily in the study of the retina from the molecular level, genetics, neurologic, and psychophysical models, electrophysiologic testing for early diagnosis of glaucoma, and early identification of retinopathy in AIDS.  He has taken a special interest in several rare diseases, including Epidermolysis Bullosa, Fabry Disease, Niemann-Pick Disease, and, in collaboration with the Ocular Oncology Service at Memorial Sloan-Kettering Cancer Center, Retinoblastoma.

Research

Selected Publications

Brodie, S.E., Knight, B.W., and Ratliff, F.: The response of the Limulus retina to moving stimuli: A prediction by Fourier synthesis, J. Gen. Physiol., 1978, 72, 129-166.

Victor, J.D. and Brodie, S.E.: Discriminable textures with identical Buffon needle statistics, Biol. Cybernetics, 1978, 31, 231-234.

Sirovich, L., Brodie, S.E., Knight, B.W.: Effects of boundaries on the responses of neural networks, Biophys. J., 1979, 28, 423-446.

Brodie, S.E.: Photographic calibration of the Hirschberg test, Invest. Ophthalmol. Visual Sci., 1987, 28, 736-742.

Brodie, S.E. and Friedman, A.H., Retinal dysfunction as an initial ophthalmic sign in AIDS. British J. of Ophthalmology, 1990 74:49-51.

Brodie, S.E., Corneal topography and the Hirschberg Test, Applied Optics, 1992, 31:3627-3631.

Brodie, S.E. and Conte, M.M., Dependence of the Pattern-ERG on Variations of the Stimulus Pattern, Clin. Vis. Sci., 1992, 7:283-291.

Brodie, S.E., Goncalves, J., and Naidu, E.M., Combined amplitude and phase criteria for evaluation of macular electroretinograms, Ophthalmology 1992, 99:522-530.

Lin, A.N., Murphy, F., Brodie, S.E., Carter, D.M., Review of Ophthalmic findings in 204 Patients With Epidermolysis Bullosa, Amer. J. Ophthalmol., 1994, 118:384-390.

Brodie, S.E., An Indication for “Granny Glasses”, Survey of Ophthalmology, 1995, 39:517-518.

Pollack, A.L, Brodie, S.E. Diagnostic Yield of the Routine Dilated Fundus Examination, Ophthalmology, 105:382-386, 1998. (see also Letter to the Editor, Ophthalmology, 105:1984-1985, 1998)

Gow, A., Southwood, C.M., Li, J.S., Pariali, M., Riordan, G.P., Brodie, S.E., Danias, J., Bronstein J.M., Kachar, B, and Lazzarini R.A., CNS myelin and sertoli cell tight junction strands are absent in OSP/Claudin-11 Null Mice, Cell 99:649-659, 1999.

Eng CM, Banikazemi M, Gordon RE, Goldman M, Phelps R, Kim L, Gass A, Winston J, Dikman S, Fallon JT, Brodie S, Stacy CB, Mehta D, Parsons R, Norton K, O'Callaghan M, Desnick RJ.  A Phase 1/2 Clinical Trial of Enzyme Replacement in Fabry Disease: Pharmacokinetic, Substrate Clearance, and Safety Studies. Am J Hum Genet. 68(3):711-722, 2001.

McGovern MM, Wasserstein MP, Aron A, Desnick RJ, Schuchman EH, Brodie SE, Ocular Manifestations of Niemann-Pick Disease Type B, Ophthalmology, 111: 1424-1427, 2004.

Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC, Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking αvβ5 integrin. J Exp Med, 200:1539-1545, 2004.

Abramson DH, Dunkel IJ, Brodie SE, Kim JW, Gobin YP. A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma: initial results. Ophthalmology. 2008 Aug;115(8):1398-404.

Brodie SE, Gobin YP, Dunkel IJ, Kim JW, Abramson DH, Persistence of retinal function after selective ophthalmic artery chemotherapy infusion for retinoblastoma. Documenta Ophthalmologica,  Ophthalmol 2009 Aug;119(1):13-22.

Gobin YP, Dunkel IJ, Marr BP, Brodie SE, Abramson DH, Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience, Arch Ophthalmol 2011 Jun;129(6):732-737.

Fuchs LR, Matthieu R, Inster-Moati I, Couette L, Dufier J-L, de Lonlay P, Brodie SE, Ocular manifestations of cobalamin C type methlymalonic aciduria with homocystinuria, Journal of AAPOS, 2012, in press.

 

Clinical interests:

  • Medical Retina:
    • inherited, metabolic, and degenerative diseases of the retina,
    • diabetic retinopathy
    • age-related macular degeneration,
    • retinitis pigmentosa
  • Clinical electrophysiology and psychophysics:
    • electroretinography,
      • full-field ('Ganzfeld') technique
      • focal ERG
      • pattern ERG
    • electro-oculography,
    • visual evoked potentials,
    • dark adaptometry,
    • contrast sensitivity,
    • color vision
  • Epidermolysis Bullosa
  • Occupational ophthalmology
  • Retinoblastoma 
  • General ophthalmology

Research Interests:

  • Clinical electrophysiology: focal and pattern electroretinography
  • Early diagnosis of glaucoma
  • Theory of corneal topography
  • ERG monitoring for retinal toxicity:
  • Plaquenil
  • Sabril

 

Software

Dr. Brodie has written several computer programs for the use of professionals in vision science and ophthalmology. These include software for

·         An Excel spreadsheet nomogram for Calibration of ERG flash and background illumination using a standard photographic flash-capable light meter

·         Glaucoma screening by means of tests of blue-yellow chromatic contrast sensitivity after Arden, using standard PC color monitors

·         A realization of the Berson test plates for Blue-cone achromats

·         Demonstration of color-vision abnormalities using standard PC color monitors

These programs will be provided at no charge to those interested on an “as-is” basis on request, by email.

 

Publications

Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie S, Danias J, Bronstein JM, Kachar B, Lazzarini R. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell 1999 Dec 10; 99(6): 649-59.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Brodie did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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