Robert Rosenson

PROFESSOR Medicine, Cardiology

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Email

robert.rosenson@mssm.edu

Specialty

Cardiology

Certifications

Cardiovascular Disease
American Board of Internal Medicine

Clinical Focus

Acute Coronary Syndrome
Cardiac Arrest
Cardiomyopathy
Cardiovascular Disease
General Cardiology
Heart Attack/Acute Coronary Syndrome
Heart Disease
Homocystinuria
Hyperlipidemia/High Cholesterol
Metabolic Syndrome
Renovascular Hypertension
Stroke
Tachycardia
Type 1 Diabetes
Type 2 Diabetes

Education

MD, Tulane University
Residency, Internal Medicine
Brigham and Women's Hospital
Fellowship, Cardiovascular
University of Chicago Hospitals

Biography

Robert S. Rosenson, MD, FACC, is Professor of Medicine at the Icahn School of Medicine at Mount Sinai where he serves as Director of Cardiometabolic Disorders.

Dr. Rosenson earned his medical degree from Tulane University in New Orleans, Louisiana. He then served his residency in medicine at Brigham and Women’s Hospital in Boston, Massachusetts. He later completed a fellowship in cardiology at the University of Chicago that was followed by an additional year of training as a Research Associate in lipoprotein metabolism.

Dr. Rosenson has been involved in numerous grant-supported research investigations studying the effects of lipid-lowering therapy, hypoglycemic therapy, and antihypertensive agents in inflammation, thrombogenesis, and rheology. He has served as Principal Investigator on a number of NIH-funded research studies, pharmaceutical-sponsored drug trials, and multicenter studies. Recently, he served as Global Principal Investigator of the PLASMA I, PLASMA II and FRANCIS trials. He has been an invited speaker at more than 200 national and international association meetings, grand rounds, and symposia. He has authored nearly a total of 600 journal articles, book chapters, abstracts, and electronic publications for UpToDate Medicine.

At Mount Sinai Medical Center, he will conduct outpatient sessions that address comprehensive risk factor modification in patients with atherosclerotic vascular disease, primary and secondary prevention of cardiovascular disease in diabetes patients. His particular interest relates to lipoprotein disorders.

Publications

Rosenson RS, Hurt-Camejo E. Phospholipase A2 enzymes and the risk of atherosclerosis. European heart journal 2012 Dec; 33(23).

Rosenson RS, Stafforini DM. Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2. Journal of lipid research 2012 Sep; 53(9).

Rosenson RS, Brewer HB, Davidson WS, Fayad ZA, Fuster V, Goldstein J, Hellerstein M, Jiang XC, Phillips MC, Rader DJ, Remaley AT, Rothblat GH, Tall AR, Yvan-Charvet L. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation 2012 Apr; 125(15).

Rosenson RS, Brewer HB, Chapman MJ, Fazio S, Hussain MM, Kontush A, Krauss RM, Otvos JD, Remaley AT, Schaefer EJ. HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events. Clinical chemistry 2011 Mar; 57(3).

Rosenson RS, Carlson DM, Kelly MT, Setze CM, Hirshberg B, Stolzenbach JC, Williams LA. Achievement of lipid targets with the combination of rosuvastatin and fenofibric Acid in patients with type 2 diabetes mellitus. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2011 Feb; 25(1).

Rosenson RS, Elliott M, Stasiv Y, Hislop C. Randomized trial of an inhibitor of secretory phospholipase A2 on atherogenic lipoprotein subclasses in statin-treated patients with coronary heart disease. European heart journal 2011 Apr; 32(8).

Pignone M, Alberts MJ, Colwell JA, Cushman M, Inzucchi SE, Mukherjee D, Rosenson RS, Williams CD, Wilson PW, Kirkman MS. Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation. Diabetes care 2010 Jun; 33(6).

Rosenson RS, Davidson MH, Pourfarzib R. Underappreciated opportunities for low-density lipoprotein management in patients with cardiometabolic residual risk. Atherosclerosis 2010 Nov; 213(1).

Rosenson RS. Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients. Obesity (Silver Spring, Md.) 2009 Mar; 17(3).

Rosenson RS, Tangney CC. Antiatherothrombotic properties of statins: implications for cardiovascular event reduction. JAMA : the journal of the American Medical Association 1998 May; 279(20).

Rosenson RS, Tangney CC, Casey LC. Inhibition of proinflammatory cytokine production by pravastatin. Lancet 1999 Mar; 353(9157).

Mora S, Otvos JD, Rifai N, Rosenson RS, Buring JE, Ridker PM. Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women. Circulation 2009 Feb; 119(7).

Rosenson RS, Hislop C, McConnell D, Elliott M, Stasiv Y, Wang N, Waters DD. Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): a phase II double-blind, randomised, placebo-controlled trial. Lancet 2009 Feb; 373(9664).

Rosenson RS. Treatment with aspirin and dipyridamole is more effective than aspirin in reducing low shear blood viscosity. Microcirculation (New York, N.Y. : 1994) 2008 Oct; 15(7).

Rosenson RS, Otvos JD, Hsia J. Effects of rosuvastatin and atorvastatin on LDL and HDL particle concentrations in patients with metabolic syndrome: a randomized, double-blind, controlled study. Diabetes care 2009 Jun; 32(6).

Smith SC, Anderson JL, Cannon RO, Fadl YY, Koenig W, Libby P, Lipshultz SE, Mensah GA, Ridker PM, Rosenson R. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group. Circulation 2004 Dec; 110(25).

Rosenson RS, Hislop C, Elliott M, Stasiv Y, Goulder M, Waters D. Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients. Journal of the American College of Cardiology 2010 Sep; 56(14).

Terblanche M, Almog Y, Rosenson RS, Smith TS, Hackam DG. Statins: panacea for sepsis?. The Lancet infectious diseases 2006 Apr; 6(4).

Leiter LA, Rosenson RS, Stein E, Reckless JP, Schulte KL, Schleman M, Miller P, Palmer M, Sosef F. Efficacy and safety of rosuvastatin 40 mg versus atorvastatin 80 mg in high-risk patients with hypercholesterolemia: results of the POLARIS study. Atherosclerosis 2007 Oct; 194(2).

Smith SC, Milani RV, Arnett DK, Crouse JR, McDermott MM, Ridker PM, Rosenson RS, Taubert KA, Wilson PW. Atherosclerotic Vascular Disease Conference: Writing Group II: risk factors. Circulation 2004 Jun; 109(21).

Rosenson RS, Wolff D, Green D, Boss AH, Kensey KR. Aspirin. Aspirin does not alter native blood viscosity. Journal of thrombosis and haemostasis : JTH 2004 Feb; 2(2).

Rosenson RS, Otvos JD, Freedman DS. Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC-I) trial. The American journal of cardiology 2002 Jul; 90(2).

Mora S, Otvos JD, Rosenson RS, Pradhan A, Buring JE, Ridker PM. Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes 2010 May; 59(5).

Terblanche M, Almog Y, Rosenson RS, Smith TS, Hackam DG. Statins and sepsis: multiple modifications at multiple levels. The Lancet infectious diseases 2007 May; 7(5).

Rosenson RS. Myocardial injury: the acute phase response and lipoprotein metabolism. Journal of the American College of Cardiology 1993 Sep; 22(3).

Rosenson RS, Wolff DA, Huskin AL, Helenowski IB, Rademaker AW. Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome. Diabetes care 2007 Aug; 30(8).

Clinical Trials

Cardiovascular outcomes study to evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with a recent acute coronary syndrome (ACS) event and type 2 diabetes mellitus (T2DM)

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Rosenson during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

Abbott Laboratories; Aegerion Pharmaceuticals; Daiichi-Sankyo Co., Ltd.; F. Hoffman-La Roche Ltd.; Regeneron Pharmaceuticals; sanofi-aventis

Scientific Advisory Board:

Amgen Inc.; AstraZeneca; Daiichi-Sankyo Co., Ltd.; LipoScience Inc.

Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose.

Kowa Pharmaceuticals America, Inc.

Other Activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership.

Abbott Laboratories

Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)

LipoScience Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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