I am a board-certified radiation oncologist whose clinical practice is focused on the personalized treatment of patients with head and neck cancer, breast cancer, and lymphoma. I work closely with my colleagues in surgery, pathology, radiology, and medical oncology to develop a treatment plan that minimizes both the risk of cancer recurrence and the risk of treatment-associated toxicity. My goal is to implement radiation therapy only when needed, and to use advances in technology to target radiation to areas at risk while minimizing radiation exposure to nearby normal tissues.
I completed my residency at Memorial Sloan-Kettering Cancer Center, where I served as chief resident. I have published numerous peer-reviewed papers on a broad range of oncological topics. I serve as a reviewer for a number of cancer journals. My research interest include investigating mechanisms by which cancer invades and spreads along nerves, salivary gland cancers, optimizing the technical delivery of radiation for breast cancer patients to minimize toxicity, and investigating the optimal utilization of radiation for hematological malignancies.
MD, New York University School of Medicine
Internship, Internal Medicine
Mount Sinai Hospital
Residency, Radiation Oncology
Memorial Sloan-Kettering Cancer Center
ASTRO Annual Resident Clinical/Basic Science Research Award
National Comprehensive Cancer Network Fellows Recognition Program
Mortimer J. Lacher Lymphoma Fellowship
Samuel Spiegel Award for Academic Achievement
Medical Degree Conferred with Honors in Physiology and Neuroscience
Alpha Omega Alpha
Phi Betta Kappa
Summa Cum Laude
Organic Chemistry Achievement Award
New York University Presidential Honors Scholar
National Society of Collegiate Scholars
A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
The standard treatment for cancer of the salivary gland is surgery, and all patients will have had surgery before taking part in this study. Although the surgery may have removed your cancer, features of your disease suggest that you are at an increased risk for your cancer to re...
Phase I Study of Afatinib with Postoperative Radiation Therapy for Intermediate and High Risk Squamous Cancer of the Head and Neck (SCCHN)
This is a dose escalation trial. The purpose of this study is to determine the safest dose of Afatinib when given in combination with Radiation therapy or in combination with Radiation Therapy and chemotherapy for head and neck cancer. Afatinib is a drug that may stop...
Misiukiewicz K, Camille N, Gupta V, Bakst R, Teng M, Miles B, Genden E, Sikora A, Posner M. The role of HPV status in recurrent/metastatic squamous cell carcinoma of the head and neck. Clinical advances in hematology & oncology : H&O 2014 Dec; 12(12).
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V. Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma. Head & neck 2014 Dec; 36(12).
Lazarev S, Gupta V, Hu K, Harrison LB, Bakst R. Mucosal melanoma of the head and neck: a systematic review of the literature. International journal of radiation oncology, biology, physics 2014 Dec; 90(5).
Ko HC, Gupta V, Mourad WF, Hu KS, Harrison LB, Som PM, Bakst RL. A contouring guide for head and neck cancers with perineural invasion. Practical radiation oncology 2014; 4(6).
He S, He S, Chen CH, Deborde S, Bakst RL, Chernichenko N, McNamara WF, Lee SY, Barajas F, Yu Z, Al-Ahmadie HA, Wong RJ. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Molecular cancer research : MCR 2015 Feb; 13(2).
He S, Bakst RL, Guo T, Sun J. A combination of modified transnasal endoscopic maxillectomy via transnasal prelacrimal recess approach with or without radiotherapy for selected sinonasal malignancies. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2014 Aug;.
Patel S, Mourad WF, Wang C, Dhanireddy B, Concert C, Ryniak M, Khorsandi AS, Shourbaji RA, Li Z, Culliney B, Patel R, Bakst RL, Tran T, Shasha D, Schantz S, Persky MS, Hu KS, Harrison LB. Postoperative radiation therapy for parotid pleomorphic adenoma with close or positive margins: treatment outcomes and toxicities. Anticancer research 2014 Aug; 34(8).
Carpenter TJ, Kann B, Buckstein MH, Ko EC, Bakst RL, Misiukiewicz KJ, Posner MR, Genden EM, Gupta V. Tolerability, toxicity, and temporal implications of transoral robotic surgery (TORS) on adjuvant radiation therapy in carcinoma of the head and neck. The Annals of otology, rhinology, and laryngology 2014 Nov; 123(11).
He S, Chen CH, Chernichenko N, He S, Bakst RL, Barajas F, Deborde S, Allen PJ, Vakiani E, Yu Z, Wong RJ. GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. Proceedings of the National Academy of Sciences of the United States of America 2014 May; 111(19).
Cotter R, Blacksburg S, Carpenter T, Kann B, Bakst R, Misiukiewicz K, Posner M, Som P, Gupta V. Does response to induction chemotherapy (IC) predict locoregional control after concurrent chemoradiotherapy (CCRT) in locally advanced head and neck cancer (LAHNC)?. Oral oncology 2014 Jun; 50(6).
Misiukiewicz K, Gupta V, Bakst R, Posner M. Taxanes in cancer of the head and neck. Anti-cancer drugs 2014 May; 25(5).
Liu J, Bakst R, Phelps R, Jagannath S, Blacksburg S. Radiation therapy for secondary cutaneous plasmacytomas. Case reports in hematology 2013; 2013.
Mattes MD, Kharofa J, Zeidan YH, Tung K, Gondi V, Golden DW. Results of the 2012-2013 Association of Residents in Radiation Oncology (ARRO) job search and career planning survey of graduating residents in the United States. International journal of radiation oncology, biology, physics 2014 Jan; 88(1).
Ashamalla M, Teng MS, Brody J, Demicco E, Parikh R, Dharmarajan K, Bakst RL. A Case of a Laryngeal MALT Lymphoma in a Patient with a History of Gastric MALT. Case reports in hematology 2015; 2015.
Chernichenko N, Linkov G, Li P, Bakst RL, Chen CH, He S, Yu YA, Chen NG, Szalay AA, Fong Y, Wong RJ. Oncolytic vaccinia virus therapy of salivary gland carcinoma. JAMA otolaryngology-- head & neck surgery 2013 Feb; 139(2).
Bakst RL, Lee N, He S, Chernichenko N, Chen CH, Linkov G, Le HC, Koutcher J, Vakiani E, Wong RJ. Radiation impairs perineural invasion by modulating the nerve microenvironment. PloS one 2012; 7(6).
He S, Li P, Chen CH, Bakst RL, Chernichenko N, Yu YA, Chen N, Szalay AA, Yu Z, Fong Y, Wong RJ. Effective oncolytic vaccinia therapy for human sarcomas. The Journal of surgical research 2012 Jun; 175(2).
Bakst R, Wolden S, Yahalom J. Radiation therapy for chloroma (granulocytic sarcoma). International journal of radiation oncology, biology, physics 2012 Apr; 82(5).
Bakst RL, Tallman MS, Douer D, Yahalom J. How I treat extramedullary acute myeloid leukemia. Blood 2011 Oct; 118(14).
Bakst R, Yahalom J. Radiation therapy for leukemia cutis. Practical radiation oncology; 1(3).
Bakst RL, Dunkel IJ, Gilheeney S, Khakoo Y, Becher O, Souweidane MM, Wolden SL. Reirradiation for recurrent medulloblastoma. Cancer 2011 Nov; 117(21).
Bakst R, Jakubowski A, Yahalom J. Recurrent neurotropic chloroma: report of a case and review of the literature. Advances in hematology 2011; 2011.
Bakst RL, Lee N, Pfister DG, Zelefsky MJ, Hunt MA, Kraus DH, Wolden SL. Hypofractionated dose-painting intensity modulated radiation therapy with chemotherapy for nasopharyngeal carcinoma: a prospective trial. International journal of radiation oncology, biology, physics 2011 May; 80(1).
Bakst R, Kovarik C, Werth VP. A case of localized scleroderma in a sculptor and his wife. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2009 Dec; 15(8).
Bakst R, Merola JF, Franks AG, Sanchez M. Raynaud's phenomenon: pathogenesis and management. Journal of the American Academy of Dermatology 2008 Oct; 59(4).
Weiner HL, Bakst R, Hurlbert MS, Ruggiero J, Ahn E, Lee WS, Stephen D, Zagzag D, Joyner AL, Turnbull DH. Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer research 2002 Nov; 62(22).
Ahmed I, Dharmarajan K, Tiersten A, Bleiweiss I, Schmidt H, Green S, Bakst RL. A unique presentation of occult primary breast cancer with a review of the literature. Case reports in oncological medicine 2015; 2015.
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Dr.Bakst did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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