MS, Shanghai Institute of Cell Biology, Academia Sinica
PhD, Tufts University
Postdoc, Massachusetts General Hospital-East, Harvard Medical School
Cancer Biology [CAB], Developmental and Stem Cell Biology [DSCB]
Brunckhorst MK, Xu Y, Lu R, Yu Q. Angiopoietins promote ovarian cancer progression by establishing a procancer microenvironment. The American journal of pathology 2014 Aug; 184(8).
Gong Y, Scott E, Lu R, Xu Y, Oh WK, Yu Q. TIMP-1 promotes accumulation of cancer associated fibroblasts and cancer progression. PloS one 2013; 8(10).
Murray LB, Lau YK, Yu Q. Merlin is a negative regulator of human melanoma growth. PloS one 2012; 7(8).
Brunckhorst MK, Lerner D, Wang S, Yu Q. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer biology & therapy 2012 Jul; 13(9).
Xu Y, Stamenkovic I, Yu Q. CD44 attenuates activation of the Hippo signaling pathway and is a prime therapeutic target for glioblastoma. Cancer Res 2010 March 15; 70: 2455-2464.
Stamenkovic I, Yu Q. Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival. Curr Protein Pept Sci. 2010; 11(6): 471-484.
Brunckhorst MK, Wang H, Lu R, Yu Q. Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis. Cancer research 2010 Sep; 70(18).
Stamenkovic I, Yu Q. Shedding Light on Proteolytic Cleavage of CD44: the Responsible Sheddase and Functional Significance of Shedding. J Invest Dermatol 2009; 129(6): 1321-1324.
Lau YK, Murray LB, Houshmandi SS, Xu Y, Gutmann DH, Yu Q. Merlin is a potent inhibitor of glioma growth. Cancer Res 2008 Jul 15; 68(14): 5733-5742.
Bai Y, Liu YJ, Wang H, Xu Y, Stamenkovic I, Yu Q. Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin. Oncogene 2007 Feb 8; 26(6): 836-850.
Liu YJ, Xu Y, Yu Q. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. Oncogene 2006 Apr 20; 25(17): 2452-2467.
Yu Q. The dynamic roles of angiopoietins in tumor angiogenesis [review]. Future Oncol 2005 Aug; 1(4): 475-484.
Xu Y, Liu YJ, Yu Q. Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis. Cancer Res 2004 Sep 1; 64(17): 6119-6126.
Xu Y, Liu YJ, Yu Q. Angiopoietin-3 is tethered on the cell surface via heparan sulfate proteoglycans. J Biol Chem 2004 Sep 24; 279(39): 41179-41188.
Yu Q, Stamenkovic I. Transforming growth factor-beta facilitates breast carcinoma metastasis by promoting tumor cell survival. Clin Exp Metastasis 2004; 21(3): 235-242.
Xu Y, Yu Q. E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis. J Biol Chem 2003 Mar 7; 278(10): 8661-8668.
Yu Q, Stamenkovic I. Angiopoietin-2 is implicated in the regulation of tumor angiogenesis. The American journal of pathology 2001 Feb; 158(2).
Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes & development 2000 Jan; 14(2).
Yu Q, Stamenkovic I. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes & development 1999 Jan; 13(1).
Yu Q, Toole BP, Stamenkovic I. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. The Journal of experimental medicine 1997 Dec; 186(12).
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Dr.Yu did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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