Philippe Soriano
- PROFESSOR Developmental and Regenerative Biology
- PROFESSOR Oncological Sciences
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Research Topics
Research
Philippe Soriano's laboratory studies growth factor signaling pathways that have important roles in mouse embryonic development. In particular, our lab is interested in the general question of how biological specificity is acquired upon engagement of growth factor signaling. A major focus of our research is in craniofacial biology, where we seek to identify the pathways by which Platelet Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) signaling regulate the development of the midface and palate. We are also establishing the signaling pathways that are engaged by FGF signaling that govern the establishment of extraembryonic stem cell fate as well as the differentiation of embryonic and epiblast stem cells. For more detailed information, please consult our laboratory website.
Publications
Vasudevan HN, Soriano P. SRF Regulates Craniofacial Development through Selective Recruitment of MRTF Cofactors by PDGF Signaling. Developmental Cell 2014; 31: 332-344.
Fantauzzo KA, Soriano P. PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways.. Genes and Development 2014; 28: 1005-1017.
He F, Soriano P. A critical role for PDGFRα signaling in medial nasal process development. PLoS Genetics 2013; 9: e1003851.
Olson LE, Soriano P. PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Developmental Cell 2011; 20: 815-826.
Bush JO, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes and Development 2010; 24: 2068-2080.
Olson LE, Soriano P. Increased PDGFRα activation disrupts connective tissue development and drives systemic fibrosis . Developmental Cell 2009; 16: 303-313.
Schmahl J, Rizzolo K, Soriano P. The PDGF signaling pathway controls multiple steroid producing lineages. Genes and Development 2008; 22: 3255-3267.
Schmahl J, Raymond CS, Soriano P. PDGF signaling specificity is mediated through multiple immediate early genes. Nature Genetics 2007; 39: 52-60.
Davy A, Bush JO, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies cranio-frontonasal syndrome. PLOS Biology 2006; 4: 1763-1776.
Hoch RV, Soriano P. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 2006; 133: 663-673.
Tallquist MD, French WJ, Soriano P. Additive effects of PDGF receptor β signaling pathways in vascular smooth muscle cell development. PLOS Biology 2003; 1: 288-299.
Hoch RV, Soriano P. PDGF roles in animal development. Development 2003; 130: 4769-4784.
Klinghoffer RA, Hamilton TG, Hoch R, Soriano P. An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development. Developmental Cell 2002; 2: 103-113.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Soriano during 2014 and/or 2015. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Royalty Payments:
- Fred Hutchinson Cancer Research Center
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
Developmental and Regenerative Biology, Box 1020
1468 Madison Avenue
New York, NY 10029
Annenberg Building Floor 25 Room 70D
1468 Madison Avenue
New York, NY 10029
Fax: 212-860-9279
