Cancer Genetics, Cell Biology, Developmental Biology, Embryology, Genetics, Growth Factors and Receptors, Human Genetics and Genetic Disorders, Knockout Mice, Oncogenes, Organogenesis, Protein Kinases, Skeletal Biology, Stem Cells, Transgenic Mice
Cancer Biology [CAB], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU]
PhD, University of Paris
Postdoctoral, Whitehead Institute, Massachusetts Institute of Technology
Editor, Developmental Biology
NIH MERIT Award
Pew Scholar in the Biomedical Sciences
Howard Hughes Medical Institute
Philippe Soriano's laboratory studies growth factor signaling pathways that have important roles in mouse embryonic development. In particular, our lab is interested in the general question of how biological specificity is acquired upon engagement of growth factor signaling. A major focus of our research is in craniofacial biology, where we seek to identify the pathways by which Platelet Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) signaling regulate the development of the midface and palate. We are also establishing the signaling pathways that are engaged by FGF signaling that govern the establishment of extraembryonic stem cell fate as well as the differentiation of embryonic and epiblast stem cells. For more detailed information, please consult our laboratory website.
Brewer JR, Molotkov A, Mazot P, Hoch RV, Soriano P. Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes & Development 2015; 29: 1863-1874.
Vasudevan HN, Mazot P, He F, Soriano P. Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. eLife 2015; 4: e07186.
Vasudevan HN, Soriano P. SRF Regulates Craniofacial Development through Selective Recruitment of MRTF Cofactors by PDGF Signaling. Developmental Cell 2014; 31: 332-344.
Fantauzzo KA, Soriano P. PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways.. Genes and Development 2014; 28: 1005-1017.
He F, Soriano P. A critical role for PDGFRα signaling in medial nasal process development. PLoS Genetics 2013; 9: e1003851.
Olson LE, Soriano P. PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Developmental Cell 2011; 20: 815-826.
Bush JO, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes and Development 2010; 24: 2068-2080.
Olson LE, Soriano P. Increased PDGFRα activation disrupts connective tissue development and drives systemic fibrosis . Developmental Cell 2009; 16: 303-313.
Schmahl J, Raymond CS, Soriano P. PDGF signaling specificity is mediated through multiple immediate early genes. Nature Genetics 2007; 39: 52-60.
Hoch RV, Soriano P. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 2006; 133: 663-673.
Tallquist MD, French WJ, Soriano P. Additive effects of PDGF receptor β signaling pathways in vascular smooth muscle cell development. PLOS Biology 2003; 1: 288-299.
Klinghoffer RA, Hamilton TG, Hoch R, Soriano P. An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development. Developmental Cell 2002; 2: 103-113.
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Below are financial relationships with industry reported by Dr. Soriano during 2015 and/or 2016. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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