Dr Wang is working to develop integrative network models to combine large-scale matched genomic (whole-genome sequencing), transcriptomic (bulk and single cell resolution), proteomic and epigenomic (DNA methylation and ATAC-seq) data generated from diseased and control tissues, with a special focus on neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. By decoding the hidden interconnected relationships among a large network of genes/proteins that underlie the disease pathology, he aims to identify new pathways/genes/cell populations that drive the key pathways of disease, in the hope that this may lead to novel therapeutics to treat the diseases.
