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Michael Ross

  • ASSOCIATE PROFESSOR Medicine, Nephrology
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Specialty

Certifications

  • Nephrology

  • American Board of Internal Medicine

Education

  • MD, New York University

  • Residency, Internal Medicine
    Duke University Hospital

  • Fellowship, Renal Disease
    Mount Sinai Hospital

Biography


Research

Study of the role of FAT10 in the pathogenesis of renal disease

We have determined that the ubiquitin-like protein FAT10 is one of the most upregulated genes in renal epithelial cells after HIV-infection. We also have shown that FAT10 is upregulated in renal epithelial cells kidney tissue from patients with HIVAN and autosomal dominant polycystic kidney disease. Moreover, we have found that FAT10 expression induces apoptosis in renal epithelial cells and that blocking FAT10 expression protects renal epithelial cells against HIV-induced apoptosis. We are studying the molecular mechanisms by which FAT10 induces apoptosis and cell cycle dysregulation. We employ a wide array of cutting edge molecular techniques including molecular cloning, quantitative PCR, confocal microscopy, immunoprecipitation, and creation and characterization of transgenic models of renal disease.

Microarray analysis of HIV-1-infected renal epithelial cells

HIV-associated nephropathy (HIVAN) is the leading cause of end stage renal disease among HIV-infected patients. HIV infection of renal epithelial cells is responsible for progression of renal failure in HIVAN. We are using oligonucleotide microarrays to examine differential gene expression in human renal epithelial cells following infection by HIV-1 in vitro. Using this approach, we are able to profile the expression of thousands of cellular genes at multiple time points after infection by HIV-1. We have identified several candidate genes that may be important in the pathogenesis of HIVAN and we are studying the roles of these genes in causing progressive renal failure in patients with HIVAN.

Publications

Ross MJ, Klotman PE, Winston JA. HIV-associated nephropathy: case study and review of the literature. AIDS Patient Care and STDs 2000; 14(12): 637-45.

Ross MJ, Bruggeman LA, Wilson PW, Klotman PE. Microcyst formation and HIV-1 gene expression occur in multiple nephron segments in HIV-associated nephropathy. J Am Soc Nephrol 2001; 12(12): 2645-51.

Ross M, Klotman PE. Recent progress in HIV-associated nephropathy [review]. J Am Soc Nephrol 2002 Dec; 13(12): 2997-3004.

Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. J Am Soc Nephrol 2004 Jul; 15(7): 1721-30.

Ross M, Klotman PE. HIV-associated nephropathy. AIDS 2004 May 21; 18(8): 1089-99.

Ross MJ, Martinka S, D'Agati VD, Bruggeman LA. NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathy. J Am Soc Nephrol 2005 Aug; 16(8): 2403-11.

Lu TC, Ross M. HIV-associated nephropathy: a brief review. Mt Sinai J Med 2005 May; 72(3): 193-9.

Schwartz EJ, Szczech LA, Ross MJ, Klotman ME, Winston JA, Klotman PE. Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease. J Am Soc Nephrol 2005 Aug; 16(8): 2412-20.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Ross did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Address

Annenberg Building Floor 23rd Floor Room Room 40
1468 Madison Avenue
New York, NY 10029


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