Meng Wu | Mount Sinai

About Me

Meng Wu received his PhD in Biochemistry and Molecular Biology from Peking Union Medical College in China, studying chromatin remodeling in neural differentiation. He had his postdoctoral training in the Center for Molecular Cardiology at Mount Sinai, focusing on the functions of epigenetic regulators in the formation of the cardiac conduction system. He is currently an Instructor in Dr. Ethylin Wang Jabs’ group studying molecular mechanisms of human malformation disorders including craniosynostosis, neural tube defects and Roberts syndrome.

Language

English

Position

ASSISTANT PROFESSOR | Genetics and Genomic Sciences

Research Topics

Bone Biology, Cartilage Biology, Chromatin, Developmental Biology, Epigenetics, Epigenomics, Folates, Gene Expressions, Gene Regulation, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Molecular Biology, Stem Cells, Structural Biology, Systems Biology, Transcription Factors

Multi-Disciplinary Training Areas

Development Regeneration and Stem Cells [DRS]

Education

Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai

BS, Zhejiang University

PhD, Peking Union Medical College

Research

Craniosynostosis Network is an organized and synergistic research program to understand the genetic basis and developmental mechanism of craniosynostosis (http://labs.icahn.mssm.edu/peterlab/craniosynostosis-network/). Project III: Systems Biology of Bone in Coronal Nonsyndromic Craniosynostosis We generate and differentiate patient-derived iPS cells and analyze the transcriptomic profiles during osteogenic differentiation to study systems biology of coronal nonsyndromic craniosynostosis (cNSC). An in vitro osteogenic differentiation model has been developed and high-throughput RNA-seq datasets on human normal and cNSC mesenchymal cells, preosteoblasts and osteoblasts are used to capture the genetic regulation of gene expression and guide network construction.