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Megan Shaw

  • ASSOCIATE PROFESSOR Microbiology
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Training Areas

Education

  • B.Sc. (Med)Honors, University of Cape Town

  • Ph.D., University of Glasgow

  • B.Sc., University of Cape Town

Biography


    Video

    Watch a video featuring the Microbiology and Virology PhD Graduate School Program.

Research

The Shaw laboratory is interested in the interactions that occur between RNA viruses and their hosts at the molecular level and how this knowledge may be used for designing better vaccines and for finding new antiviral drugs. The research involves basic molecular biology and virology techniques combined with RNAi, proteomics and high-throughput screening of small molecular weight compounds.

Our major focus is on identifying new antivirals for influenza virus as well as host proteins that are required by the virus and therefore may serve as novel drug targets.  Another interest of the Shaw lab is the host antiviral response and specifically the mechanisms that viruses use to block this response. Viral proteins that can inhibit the host innate immune response are important determinants of viral pathogenicity. Understanding their mechanism of action and identifying compounds that prevent their activity will aid in the design attenuated viruses for vaccine purposes or in the discovery of new antiviral drugs. One virus of particular interest to us is Nipah virus, with is a highly pathogenic, emerging paramyxovirus. Nipah virus encodes multiple proteins that inhibit the antiviral response our goal is to determine their mechanisms of action and their individual contributions to virus pathogenesis. In collaboration with the Palese and Garcia-Sastre laboratories, we are also involved in studies to find activators of the innate immune response that may serve as general antivirals as well as vaccine adjuvants.

Students: Leighland Feinman, Nicole Glennon

Postdoctoral fellows: Oliver Dibben, Ph.D., Yuhong Liang, Ph.D., Kris White, Ph.D.

Research Personnel: Pablo Abreu Jr.

Publications

Shaw Ml, Palese P. Orthomyxoviridae: The Viruses and Their Replication. In: In Fields Virology 6th edition . Lippincott Williams & Wilkins, Philadelphia;.

Shaw ML. The host interactome of influenza virus presents new potential targets for antiviral drugs. Reviews in medical virology 2011 Nov; 21(6).

Hoffmann HH, Kunz A, Simon VA, Palese P, Shaw ML. A broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 2011 Apr; 108(14).

Stertz S, Shaw ML. Uncovering the global host cell requirements for influenza virus replication via RNAi screening. Microbes and infection / Institut Pasteur 2011 May; 13(5).

Seto J, Qiao L, Guenzel CA, Xiao S, Shaw ML, Hayot F, Sealfon SC. Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study. Journal of virology 2010 Nov; 84(21).

König R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrews SE, Bandyopadhyay S, De Jesus P, Tu BP, Pache L, Shih C, Orth A, Bonamy G, Miraglia L, Ideker T, García-Sastre A, Young JA, Palese P, Shaw ML, Chanda SK. Human host factors required for influenza virus replication. Nature 2010 Feb; 463(7282).

Ciancanelli MJ, Volchkova VA, Shaw ML, Volchkov VE, Basler CF. Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism. Journal of virology 2009 Aug; 83(16): 7828-41.

Shaw ML. Henipaviruses employ a multifaceted approach to evade the antiviral interferon response. Viruses 2009 Dec; 1(3).

Kulkarni S, Volchkova V, Volchkov V, Shaw ML. Nipah Virus Edits its P Gene at High Frequency to Express the V and W Proteins. Journal of Virology 2009; 83(8): 3982-7.

Palese P, Shaw ML. Orthomyxoviruses: Molecular biology. In: Encyclopedia of Virology 3rd edition. Oxford, U.K, Elsevier, 2009. pp483-489.

Hoffmann HH, Palese P, Shaw ML. Modulation of Influenza Virus Replication by Alteration of Sodium Ion Transport and Protein Kinase C activity. Antiviral Research 2008; 80: 124-134.

Shaw ML, Stone KL, Colangelo CM, Gulcicek EE, Palese P. Cellular proteins in influenza virus particles. PLoS pathogens 2008 Jun; 4(6).

Palese P, Shaw ML. Orthomyxoviridae: The Viruses and Their Replication. In: Fields Virology 5th edition. Philadelphia, Lippincott Williams & Wilkins; 2007. pp1647-1689.

Reid SP, Leung LW, Hartman AL, Martinez O, Shaw ML, Carbonnelle C, Volchkov VE, Nichol ST, Basler CF. Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. Journal of virology 2006 Jun; 80(11).

Shaw ML, Cardenas WB, Zamarin D, Palese P, Basler CF. Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways. Journal of virology 2005 May; 79(10).

Shaw ML, García-Sastre A, Palese P, Basler CF. Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively. Journal of virology 2004 Jun; 78(11).

Park MS, Shaw ML, Muñoz-Jordan J, Cros JF, Nakaya T, Bouvier N, Palese P, García-Sastre A, Basler CF. Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. Journal of virology 2003 Jan; 77(2).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Shaw during 2013 and/or 2014. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose.

  • Merck & Co., Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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