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Antivirals, Biodefense, Immune Antagonism, Infectious Disease, Influenza Virus, Nipah Virus, Viruses and Virology
BSc, University of Cape Town
BSc (Med)Honors, University of Cape Town
PhD, University of Glasgow
Students: Leighland Feinman, Nicole Glennon, Grant Beyleveld, Ryan O'Hanlon
Postdoctoral fellows: Oliver Dibben, Ph.D., Yuhong Liang, Ph.D., Kris White, Ph.D., Matthew Urbanowski, Ph.D., Thibaut Vausselin, Ph.D.
Research Personnel: Pablo Abreu Jr., Payal Pradhan
The Shaw laboratory is interested in the interactions that occur between RNA viruses and their hosts at the molecular level and how this knowledge may be used for understanding viral pathogenesis and for developing new antiviral drugs. The research involves basic molecular biology and virology techniques combined with RNAi, proteomics and high-throughput screening of small molecular weight compounds.
Our major focus is on identifying new antivirals for influenza virus as well as host proteins that are required by the virus and therefore may serve as novel drug targets. Another interest of the Shaw lab is the host antiviral response and specifically the mechanisms that viruses use to block this response. One virus of particular interest to us is Nipah virus, with is a highly pathogenic, emerging paramyxovirus. Nipah virus encodes multiple proteins that inhibit the antiviral response and our goal is to determine their mechanisms of action and their individual contributions to virus pathogenesis.
Park MS, Shaw ML, Muñoz-Jordan J, Cros JF, Nakaya T, Bouvier N, Palese P, García-Sastre A, Basler CF. Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. Journal of virology 2003 Jan; 77(2).
Shaw ML, García-Sastre A, Palese P, Basler CF. Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively. Journal of virology 2004 Jun; 78(11).
Shaw ML, Cardenas WB, Zamarin D, Palese P, Basler CF. Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways. Journal of virology 2005 May; 79(10).
Reid SP, Leung LW, Hartman AL, Martinez O, Shaw ML, Carbonnelle C, Volchkov VE, Nichol ST, Basler CF. Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. Journal of virology 2006 Jun; 80(11).
Palese P, Shaw ML. Orthomyxoviridae: The Viruses and Their Replication. In: Fields Virology 5th edition. Philadelphia, Lippincott Williams & Wilkins; 2007. pp1647-1689.
Shaw ML, Stone KL, Colangelo CM, Gulcicek EE, Palese P. Cellular proteins in influenza virus particles. PLoS pathogens 2008 Jun; 4(6).
Hoffmann HH, Palese P, Shaw ML. Modulation of Influenza Virus Replication by Alteration of Sodium Ion Transport and Protein Kinase C activity. Antiviral Research 2008; 80: 124-134.
Palese P, Shaw ML. Orthomyxoviruses: Molecular biology. In: Encyclopedia of Virology 3rd edition. Oxford, U.K, Elsevier, 2009. pp483-489.
Kulkarni S, Volchkova V, Volchkov V, Shaw ML. Nipah Virus Edits its P Gene at High Frequency to Express the V and W Proteins. Journal of Virology 2009; 83(8): 3982-7.
Shaw ML. Henipaviruses employ a multifaceted approach to evade the antiviral interferon response [review]. Viruses 2009 Dec; 1(3).
Ciancanelli MJ, Volchkova VA, Shaw ML, Volchkov VE, Basler CF. Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism. Journal of virology 2009 Aug; 83(16): 7828-41.
König R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrews SE, Bandyopadhyay S, De Jesus P, Tu BP, Pache L, Shih C, Orth A, Bonamy G, Miraglia L, Ideker T, García-Sastre A, Young JA, Palese P, Shaw ML, Chanda SK. Human host factors required for influenza virus replication. Nature 2010 Feb; 463(7282).
Seto J, Qiao L, Guenzel CA, Xiao S, Shaw ML, Hayot F, Sealfon SC. Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study. Journal of virology 2010 Nov; 84(21).
Stertz S, Shaw ML. Uncovering the global host cell requirements for influenza virus replication via RNAi screening [review]. Microbes and infection / Institut Pasteur 2011 May; 13(5).
Hoffmann HH, Kunz A, Simon VA, Palese P, Shaw ML. A broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 2011 Apr; 108(14).
Shaw ML. The host interactome of influenza virus presents new potential targets for antiviral drugs [review]. Reviews in medical virology 2011 Nov; 21(6).
Shaw ML, Palese P. Orthomyxoviridae: The Viruses and Their Replication. In: Fields Virology 6th edition . Philadelphia, Lippincott Williams & Wilkins;.
Ortigoza MB, Dibben O, Maamary J, Martinez-Gil L, Leyva-Grado VH, Abreu P, Ayllon J, Palese P, Shaw ML. A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon. PLoS pathogens 2012; 8(4).
Martínez-Gil L, Ayllon J, Ortigoza MB, García-Sastre A, Shaw ML, Palese P. Identification of small molecules with type I interferon inducing properties by high-throughput screening. PloS one 2012; 7(11).
Martínez-Gil L, Goff PH, Hai R, García-Sastre A, Shaw ML, Palese P. A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant. Journal of virology 2013 Feb; 87(3).
Alamares-Sapuay JG, Martinez-Gil L, Stertz S, Miller MS, Shaw ML, Palese P. Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus. Journal of virology 2013 May; 87(10).
Beyleveld G, White KM, Ayllon J, Shaw ML. New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions [review]. Antiviral research 2013 Oct; 100(1).
Shaw ML, Klumpp K. Successes and challenges in the antiviral field [editorial]. Current opinion in virology 2013 Oct; 3(5).
Ortiz-Riaño E, Ngo N, Devito S, Eggink D, Munger J, Shaw ML, de la Torre JC, Martínez-Sobrido L. Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor. Journal of virology 2014 Jan; 88(2).
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