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Margaret Baron

  • PROFESSOR Medicine, Hematology and Medical Oncology
  • PROFESSOR Oncological Sciences
  • PROFESSOR Developmental and Regenerative Biology
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Education

  • A.B., Harvard University
    Biochemical Sciences

  • Ph.D., Massachusetts Institute of Technology
    Biology

  • M.D., Harvard Medical School
    Health Science and Technology

  • Massachusetts General Hospital
    Internal Medicine

  • Harvard University
    Biochemistry & Molecular Biology

Biography


    Margaret H. Baron, MD PhD, is Fishberg Professor of Medicine in Hematology, Director of Hematology and Medical Oncology Research, and a member of the Tisch Cancer Institute (TCI) and Black Family Stem Cell Institute (BFSCI).  Dr. Baron is an established scientist who has over 24 years of continuous, independent NIH-sponsored research funding in hematopoiesis and a publication record spanning protein biochemistry, virology, cell biology, developmental biology, and stem cell biology.  She is well known for her work on the plasticity of the differentiated state, globin gene regulation, and developmental hematopoiesis.

    Dr. Baron is a graduate of the Harvard-M.I.T. Program in Health Sciences and Technology (H.S.T.) and holds degrees from Harvard (A.B.), Harvard Medical School (M.D.) and M.I.T. (Ph.D.).  She trained in the laboratories of David Baltimore (Ph.D. thesis) and Tom Maniatis (postdoc).  Her first independent faculty position was in The Biological Laboratories at Harvard U., where she spent 8 years as an assistant and then associate professor before moving to a tenured position at Mount Sinai in 1997, with an important goal of helping to expand the hematopoiesis and stem cell biology research programs at her new institution.  She served for 18 months (2006-2007) as Interim Co-Director of the BFSCI.  She is currently Director of the Program in Hematology and Blood Disorders (Division of Hematology and Medical Oncology) and Program Director of an NIH-funded T32 Research Training Program in Molecular and Cellular Hematology (which can support postdoc and clinical fellows).

    Dr. Baron is a dedicated educator, having developed and directed courses for PhD and MD/PhD students at Harvard and at Mount Sinai.  She is co-founder and Co-Director for the Developmental and Stem Cell Biology (DSCB) Multidisciplinary Training Area (MTA) for PhD and MD/PhD students.  She has served as a member of the Steering Committee for the Graduate School of Biomedical Sciences, Assistant Director of the Medical Scientists Training Program (MSTP), and Co-Director for the former Mechanisms of Disease and Therapies Multidisciplinary Training Area (MTA).  


    To read more about Dr. Baron's research, please visit the Baron Laboratory website.

     

Awards

  • 2012-13 -
    Fellow
    Executive Leadership in Academic Medicine (ELAM) program

  • 2011 - Present
    Elected Member
    Association of American Physicians (AAP)

  • 2004 -
    Research Recognition Award
    American Cancer Society

  • 2001 - Present
    Irene and Dr. Arthur M. Fishberg Professor of Medicine
    Mount Sinai School of Medicine

  • 2000 - Present
    Elected Member
    American Society for Clinical Investigation (ASCI)

  • 1989-92 - 1992
    Basil O'Connor Scholar Award
    March of Dimes

  • 1987-94 - 1994
    Scholar Award
    Lucille P. Markey Charitable Trust Scholar Award

Research

Our lab is interested in molecular mechanisms of hematopoietic stem and progenitor cell fate specification and differentiation using mouse and human primary cell and ES cell models and animals.  We have a longstanding interest in developmental hematopoiesis in mammals.  One focus of the lab is to study signaling pathways in embryonic hematopoiesis and erythropoiesis in the mouse.  A second focus is on definitive (adult type) hematopoietic and erythroid progenitor development (mouse fetal liver or bone marrow, human progenitors from peripheral blood or bone marrow).  We are developing a high throughput screen for regulators of erythroid progenitors as well as later stages of maturation, including enucleation, and are targeting specific metabolic/hormonal pathways for detailed analysis.  Experimental approaches include classical cell and molecular biology techniques, small interfering RNA viral technologies, RNA profiling and RNAseq, novel computational methods developed by a collaborator, chromatin immunoprecipitation (ChIP), and genetic manipulation of mice.  Finally, we are beginning to apply what we have learned from our studies on embryonic red blood cells to the development of adult red blood cells in human patients with hematological diseases.

Publications

Zhang H, Nieves JL, Fraser ST, Isern J, Douvaras P, Papatsenko D, D'Souza S, Lemischka IR, Dyer MA, Baron MH. Expression of Podocalyxin separates the hematopoietic and vascular potentials of mouse ES cell-derived mesoderm. Stem Cells 2013; DOI: 10.1002/stem.1536(Epub ahead of print).

Vacaru A, Isern J, Fraser ST, Baron MH. Analysis of primitive erythroid cell proliferation and enucleation using a cyan fluorescent reporter in transgenic mice. Genesis 2013 Aug.; 51(11): 751-762.

Baron MH, Vacaru A, Nieves JL. Erythroid Development in the Mammalian Embryo. Blood Cells, Molecules and Diseases 2013; 51(4).

Baron MH. Early Embryonic Erythropoiesis … Not so Primitive After All. Stem Cells 2013; 31(5): 849-856.

Artus J, Douvaras P, Piliszek A, Isern J, Baron MH, Hadjantonakis AK. BMP4 signaling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity. Developmental biology 2012 Jan; 361(2).

Baron MH, Isern J, Fraser ST. The embryonic origins of erythropoiesis in mammals. Blood 2012 Feb; 119: 4828-4837.

Isern J, He Z, Fraser ST, Nowotschin S, Ferrer-Vacquer A, Moore R, Hadjantonakis A, Schulz V, Tuck D, Gallagher PG, Baron MH. Single Lineage Transcriptome Analysis Reveals Key Regulatory Pathways in Primitive Erythroid Progenitors in the Mouse Embryo. Blood 2011; 117: 4924-4934.

Isern J, Fraser ST, He Z, Zhang H, Baron MH. Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf. Blood 2010; 116: 3972-3980.

Zhang H, Fraser ST, Papazoglu C, Hoatlin ME, Baron MH. The Mouse Mesendoderm Gene Goosecoid is a Transcriptional Target of the Mixl1 Homeodomain Protein in Differentiating Embryonic Stem Cells. Stem Cells 2009; 27: 2884-2895.

Isern J, Fraser ST, He Z, Baron MH. The fetal liver is a niche for maturation of primitive erythroid cells. Proc Natl Acad Sci USA 2008; 105: 6662-6667.

Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E. Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc. Natl. Acad. Sci. U.S.A. 2007; 104: 20838-20843.

Fraser ST, Isern J, Baron MH. Maturation and enucleation of primitive erythroblasts is accompanied by changes in cell surface antigen expression patterns during mouse embryogenesis. Blood 2007; 109: 343-352.

Haremaki T, Fraser ST, Kuo YM, Baron MH, Weinstein DC. Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation.. Proc. Natl. Acad. Sci. U.S.A 2007; 104: 12029-12034.

Willey S, Ayuso-Sacido A, Zhang H, Fraser ST, Adlam MA, Sahr K, Kyba M, Daley GQ, Keller G, Baron MH. Acceleration of Mesoderm Development and Expansion of Hematopoietic Progenitors in Differentiating ES Cells by the Mouse Mix-Like Homeodomain Transcription Factor. Blood 2006; 107: 3122-3130.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Baron during 2013 and/or 2014. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Royalty Payments:

  • Curis Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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